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2000
Volume 26, Issue 46
  • ISSN: 1381-6128
  • E-ISSN: 1873-4286

Abstract

Background: We recently developed a liposomal nanoparticle system that can be used for drug delivery and simultaneously be monitored by optical or photoacoustic imaging devices. Here we tested the efficacy of alendronate as a homing molecule in SM-liposomes for bone targeting. Methods: Alendronate was immobilized covalently on the liposomal surface and the fluorescent dye indocyanine green was used as a payload in the liposomes. The indocyanine green delivery was analyzed by 3D optical tomography, optical fluorescence scanner, photoacoustic imaging, and by ex-vivo biodistribution studies. Results: The results show that the alendronate, coupled to the liposomal surface, increases sphingomyelin containing liposome targeting up to several-folds. Conclusion: The alendronate targeted liposomes open possibilities for an application in active bone targeting.

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/content/journals/cpd/10.2174/1381612826666200614175905
2020-12-01
2025-06-21
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  • Article Type:
    Research Article
Keyword(s): Alendronic acid; bone targeting; ICG; liposomes; multimodal imaging; sphingomyelin
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