Skip to content
2000
Volume 24, Issue 36
  • ISSN: 1381-6128
  • E-ISSN: 1873-4286

Abstract

The study of natural sources such as plants, microorganisms and marine organisms has developed interest among the scientific community in recent years for their extensive and diverse chemical composition and consequent biological potential. The search for antitumor compounds is among the lead causes that justify phytochemical studies. Although some natural products have served as FDA approved chemotherapeutic agents, there is still a demand for the search of compounds with those characteristics. The Plectranthus genus has long been used in traditional medicine, and scientific studies have already proven its undeniable value as a source of bioactive compounds. Diterpenes are the most prominent biologically active group of secondary metabolites present in this genus. In particular, abietane diterpenes have long been studied for their biological activities, namely their anti-tumoral potential. In this review, abietane diterpenes isolated from Plectranthus genus with antiproliferative, antitumoral or cytotoxic potential are reported. In addition, a correlation between this subclass of diterpenes with their mechanisms of cell death has been discussed.

Loading

Article metrics loading...

/content/journals/cpd/10.2174/1381612825666190115144241
2018-10-01
2025-07-08
Loading full text...

Full text loading...

/content/journals/cpd/10.2174/1381612825666190115144241
Loading

  • Article Type:
    Review Article
Keyword(s): abietane; antiproliferative; chemotherapeutic agents; diterpenes; Lamiaceae; Plectranthus
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test