Potential Prognostic, Diagnostic and Therapeutic Markers for In-stent Reocclusion in Advanced Age Patients After Coronary Stenting

Background: Oxidative stress and inflammatory response played important roles in advanced atherosclerosis. We tried to confirm clinical diagnostic significance of the assessments of oxidative stress and inflammatory response status with in-stent reocclusion in 283 advanced age patients (80#158;90 years) after coronary stenting. Methods: We analyzed levels of circulating superoxide dismutase 3 (SOD3), nitric oxide (NO), endothelial nitric oxide synthase (eNOS), malondialdehyde (MDA), acrolein#136;ACR#137;, and paraoxonase-1 #136;PON-1#137;in advanced age patients with in-stent restenosis and reocclusion after coronary stenting. Results: Levels of SOD3, eNOS, NO and PON-1 were lowered (P<0.001) and levels of MDA and ACR were increased (P<0.001). Conclusion: The assessments of the biomarkers of oxidative stress and inflammatory response (levels of MDA and ACR) and anti-oxidant biomarkers (levels of eNOS, NO, SOD3 and PON-1) could be considered as potential prognostic and diagnostic indicators of in-stent reocclusion in advanced age patients after coronary stenting.