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2000
Volume 21, Issue 11
  • ISSN: 1381-6128
  • E-ISSN: 1873-4286

Abstract

Childhood maltreatment (CM) is all too frequent among western societies, with an estimated prevalence of 10 to 15%. CM associates with increased risk of several psychiatric disorders, and therefore represents a worrying public and socioeconomic burden. While associated clinical outcomes are well characterized, determining by which mechanisms early-life adverse experiences affect mental health over the lifespan is a major challenge. Epigenetic mechanisms, in particular DNA methylation, represent a form of molecular memory that may modify brain function over extended periods of time, as well as serve as a bio-marker of behavioral phenotypes associated with CM. Here, we review human studies suggesting that DNA methylation is a crucial substrate mediating neurobiological consequences of CM throughout life, thereby potentiating maladaptive behavioral patterns and psychopathological risk.

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/content/journals/cpd/10.2174/1381612821666150105124928
2015-04-01
2025-05-07
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  • Article Type:
    Research Article
Keyword(s): childhood maltreatment; DNA methylation; early-life adversity; epigenetics; stress
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