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2000
Volume 20, Issue 1
  • ISSN: 1381-6128
  • E-ISSN: 1873-4286

Abstract

Background: Hepatocellular carcinoma (HCC) has high mortality partly due to acquiring drug resistance during chemotherapy treatment. Therefore, it is necessary to explore the underlying mechanism of drug resistance. Methods: We used 2-DE and MALDI-TOF-MS analysis to explore the possible molecular insight into 5-FU resistance in HCC. The differentially expressed proteins were validated by Western blot analysis. Results: We identified 102 unique proteins including p16, maspin, PRDX6, PSMB7, MYL6, PHB, and HSP27 with alteration in SMMC- 7721/5-FU. Furthermore, down-regulation of PRDX6 and PSMB7 enhanced SMMC-7721/5-FU cells to 5-FU sensitivity. Conclusions: Our study suggests that targeting drug resistant genes such as PRDX6 and PSMB7 could be a novel approach to overcome 5-FU resistance in HCC cells.

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/content/journals/cpd/10.2174/138161282001140113125143
2014-01-01
2025-06-26
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/content/journals/cpd/10.2174/138161282001140113125143
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  • Article Type:
    Research Article
Keyword(s): 5-FU; chemoresistance; Hepatocellular carcinoma; PMSB7; PRDX6
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