Skip to content
2000
Volume 20, Issue 16
  • ISSN: 1381-6128
  • E-ISSN: 1873-4286

Abstract

Neurons and neuroendocrine cells store nucleotides in vesicles and release them upon stimulation, leading to intercellular purinergic signaling. The molecular machinery responsible for the vesicular storage of nucleotides was a long standing enigma, however, recently the transporter involving in the process was identified. This article summarizes the history of vesicular storage of nucleotides and the identification of the vesicular nucleotide transporter (VNUT) responsible for the process. The significance of VNUT as a drug target to control purinergic chemical transmission is also discussed.

Loading

Article metrics loading...

/content/journals/cpd/10.2174/13816128113199990574
2014-05-01
2025-06-26
Loading full text...

Full text loading...

/content/journals/cpd/10.2174/13816128113199990574
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test