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Volume 18, Issue 8
  • ISSN: 1381-6128
  • E-ISSN: 1873-4286

Abstract

Alzheimer disease (AD) is the leading cause of dementia among elderly. Currently, no effective treatment is available for AD. Analysis of transgenic mouse models of AD has facilitated our understanding of disease mechanisms and provided valuable tools for evaluating potential therapeutic strategies. In this review, we will discuss the strengths and weaknesses of current mouse models of AD and the contribution towards understanding the pathological mechanisms and developing effective therapies.

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/content/journals/cpd/10.2174/138161212799315786
2012-03-01
2025-05-13

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  • Article Type:     Research Article
Keyword(s): Alzheimer disease; amyloid precursor protein (APP); amyloid-beta; dementia; mild cognitive impairment (MCI); mutations; neurodegeneration; synaptic dysfunction; tau; transgenic mouse models

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