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- ISSN: 1381-6128
- E-ISSN: 1873-4286
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Histamine H3 Receptor (H3R) Antagonists and Inverse Agonists in the Treatment of Sleep Disorders
- Source: Current Pharmaceutical Design, Volume 17, Issue 15, May 2011, p. 1426 - 1429
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- 01 May 2011
Abstract
After the discovery and characterization of the H3R and H4R receptors, they have become widely anticipated as potential therapeutic agents in the treatment of sleep disorders. In preliminary studies, histamine H3 receptor (H3R) antagonists and inverse agonists have demonstrated promise in the treatment of sleep disorders associated with excessive daytime sleepiness. This review article summarizes the current research in this area and characteristics of H3R and H3R antagonists and inverse agonists in development.
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