Skip to content
2000
Volume 16, Issue 19
  • ISSN: 1381-6128
  • E-ISSN: 1873-4286

Abstract

Human laboratory studies have a rich history in the alcoholism field and several important determinants of alcohol use disorders have been successfully modeled under controlled laboratory conditions. Laboratory paradigms have been employed to identify biobehavioral risk markers for alcohol misuse and more recently, have been integrated with behavioral genetic, neuroimaging, and pharmacological approaches to further elucidate the neuropathophysiology of addiction and to screen for efficacious treatments. This review will address the rationale and application of human laboratory models to advance pharmacotherapy development for alcohol dependence. It is argued that when properly implemented, laboratory models may help scientists and clinicians understand mechanisms of pharmacotherapy response, which in turn may inform efforts to optimize the currently available and newly developed treatments for alcoholism. Limitations and future directions are discussed.

Loading

Article metrics loading...

/content/journals/cpd/10.2174/138161210791516422
2010-06-01
2025-05-12
Loading full text...

Full text loading...

/content/journals/cpd/10.2174/138161210791516422
Loading

  • Article Type:
    Research Article
Keyword(s): Alcohol; craving; genetics; laboratory studies; pharmacotherapy
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test