oa Editorial [Low Grade Inflammation as a Common Pathogenetic Denominator in Age-Related Diseases: Novel Drug Targets for Anti-Ageing Strategies and Successful Ageing Achievement. PART I. (Executive Editors: Calogero Caruso Thea Magrone and Emilio Jirilllo)]

Due to the high number of age-dependent diseases and the complexity of the therapeutic interventions this hot topic has been splitted into two parts. In Part I the physiopathology of immunosenescence; the age-related diseases and therapeutic attempts; the mechanisms of neurodegeneration; the relationship between cancer and ageing will be discussed. Candore and associates [1] will review the main mechanisms of low grade inflammation and related diseases in aging. Pinti and associates [2] and Colonna-Romano and associates [3] will illustrate the T cell homeostasis and the B cell compartment in centenarians, respectively. Cevenini and associates [4], Guiglia and associates [5], Abate and associates (6), Campisi and associates [7] and Giannola and associates [8] will discuss on new anti-ageing therapeutics with special reference to innovative sites of drug delivery. Govoni and associates [9] Mura and associates [10], Di Bona and associates [11], Alcaro and associates [12], Lanni and associates [13] will focus on the senescence of the brain and on new anti-Alzheimer agents. Balistreri and associates [14], Menna and associates [15], Moseniak and Sikora [16] and Petta and Craxì [17] will discuss on the cancer risk and proinflammatory genotypes as well as cancer prevention.