Polyunsaturated Fatty Acids and Cardiovascular Disease

Ivan Calzolari; Stefano Fumagalli; Niccolo Marchionni; Mauro Di Bari

doi:10.2174/138161209789909755

ISSN: 1381-6128
E-ISSN: 1873-4286

Polyunsaturated Fatty Acids and Cardiovascular Disease
Authors: Ivan Calzolari¹, Stefano Fumagalli², Niccolo Marchionni³ and Mauro Di Bari⁴
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¹ Department of Critical Care Medicine and Surgery, Unit of Gerontology and Geriatrics, University of Florence, via delle Oblate, 4, 50141 Florence, Italy. ² Department of Critical Care Medicine and Surgery, Unit of Gerontology and Geriatrics, University of Florence, via delle Oblate, 4, 50141 Florence, Italy. ³ Department of Critical Care Medicine and Surgery, Unit of Gerontology and Geriatrics, University of Florence, via delle Oblate, 4, 50141 Florence, Italy. ⁴ Department of Critical Care Medicine and Surgery, Unit of Gerontology and Geriatrics, University of Florence, via delle Oblate, 4, 50141 Florence, Italy.
Source: Current Pharmaceutical Design, Volume 15, Issue 36, Dec 2009, p. 4094 - 4102
DOI: https://doi.org/10.2174/138161209789909755
- Available online: 01 Dec 2009

Abstract

Several observational and experimental studies show the beneficial effects of ω-3 poly-unsaturated fatty acids (PUFA) in cardiovascular disease. The results from such studies justify supplementation of ω-3 PUFA in primary and secondary prevention of several clinical conditions, including coronary heart disease, sudden cardiac death and heart failure. Supplementation of ω-3 PUFA is also indicated as monotherapy in the treatment of hypertriglyceridemia. Analysis of their biological actions suggests a variety of anti-arrhythmic, anti-thrombotic, anti-atherosclerotic and antiinflammatory mechanisms underlying their clinical benefits.

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2009-12-01

2025-06-01

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Article Type: Research Article

Keyword(s): cardiovascular disease; coronary heart disease; heart failure; Polyunsaturated fatty acids; sudden death

Polyunsaturated Fatty Acids and Cardiovascular Disease

Abstract

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