Skip to content
2000
Volume 14, Issue 36
  • ISSN: 1381-6128
  • E-ISSN: 1873-4286

Abstract

Macrophage migration inhibitor factor (MIF) is a highly conserved and evolutionarily ancient mediator with pleiotropic effects that has been implicated in tumor growth and progression. MIF's function is unique among cytokines and its effects extend to multiple processes fundamental to tumorigenesis such as tumor proliferation, evasion of apoptosis, angiogenesis and invasion. These pleiotropic functional aspects are paralleled by MIF's unique signaling properties, which involve activation of the ERK-1/2 and AKT pathways and the regulation of JAB1, p53, SCF ubiquitin ligases and HIF-1. These properties reflect features central to growth regulation, apoptosis and cell cycle control than is typical for an immune cytokine. The significance of these pro-tumorigenic properties has found support in several in vitro and in vivo models of cancer and in the positive association between MIF production and tumor aggressiveness and metastatic potential in a variety of human tumors.

Loading

Article metrics loading...

/content/journals/cpd/10.2174/138161208786898608
2008-12-01
2025-06-01
Loading full text...

Full text loading...

/content/journals/cpd/10.2174/138161208786898608
Loading

  • Article Type:
    Research Article
Keyword(s): angiogenesis; CD44; CD74; HIF-1; Macrophage migration inhibitory factor; P53; TAM; tumor progression
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test