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2000
Volume 11, Issue 17
  • ISSN: 1381-6128
  • E-ISSN: 1873-4286

Abstract

Asymmetric dimethylarginine (ADMA) is an endogenously occurring methylarginine that inhibits nitric oxide synthesis. Plasma levels of methylarginines increase in renal failure and certain cardiovascular pathologies, and in patients with end stage renal failure the level of ADMA predicts the risk of cardiovascular events and overall mortality. The object of this review is to describe the mechanisms of ADMA synthesis, metabolism and uptake and to outline techniques for measuring ADMA and the pathological states in which ADMA levels are altered.

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/content/journals/cpd/10.2174/1381612054367364
2005-07-01
2025-05-24
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