Skip to content
2000
Volume 9, Issue 16
  • ISSN: 1381-6128
  • E-ISSN: 1873-4286

Abstract

Lactoferricin (LFcin) was initially identified as an antimicrobial peptide derived by pepsin digestion of lactoferrin (LF), a multifunctional innate-defense protein in milk. Various synthetic analogs of LFcin have also been reported. LFcin inhibits a diverse range of microorganisms such as gram-negative bacteria, gram-positive bacteria, yeast, filamentous fungi, and parasitic protozoa, including some antibiotic-resistant pathogens. LFcin kills target organisms by membrane perturbation and acts synergistically with some antimicrobial agents. LFcin exhibits numerous biological activities in common with those of LF. Whereas LFcin suppresses the activation of innate immunity by microbial components such as lipopolysaccharide (LPS) and CpG DNA, the peptide itself activates immunity. Administration of LFcin analogs has been shown to protect the host via direct antimicrobial activity and immunostimulatory effects in several infection models of mice. Here we present a comprehensive review of investigations of LFcin and related peptides.

Loading

Article metrics loading...

/content/journals/cpd/10.2174/1381612033454829
2003-06-01
2024-11-21
Loading full text...

Full text loading...

/content/journals/cpd/10.2174/1381612033454829
Loading

  • Article Type:
    Review Article
Keyword(s): antimicrobial; immunomodulation; lactoferricin; lactoferrin; lfcin; milk; multifunctional; peptide
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test