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Volume 31, Issue 12
  • ISSN: 1381-6128
  • E-ISSN: 1873-4286

Abstract

Hepatotoxicity is a critical health hazard, primarily contributing to the increased incidence of deaths globally. The liver is one of the major and extremely vital organs of the human body. Autoimmune diseases, viruses, exposure to toxicants such as carcinogens, and changes in eating habits can all cause liver problems, among other things. Free radical generation, together with raised enzyme levels including SGOT, SGPT, and total bilirubin, are among the pathological changes set off by liver injury. Hepatotoxicity causes changes in cells, such as eosinophilic cytoplasm, nuclear pyknosis, fatty degeneration, too many liver lesions, and hepatic centrilobular necrosis due to lipid peroxidation. Researchers have used animal models to investigate liver diseases and toxicities. Drugs such as azathioprine, alcoholism, paracetamol intoxication, and anti-tuberculosis drugs are some of the most common causes of liver toxicity. These toxins cause calcium ions (Ca2+), reactive oxygen species (ROS), and inflammatory mediators to be released inside cells. This activates immune cells like NK cells, NKT cells, and Kupffer cells. These signaling pathways also play roles in hepatotoxicity. Due to its pathogenesis, no effective drug is currently available for hepatotoxicity due to a lack of understanding related to the signaling factors involved in it. The paper primarily examines different experimental models of hepatotoxicity, including non-invasive and invasive methods, as well as genetic models. As such, these models are crucial tools in advancing our understanding of hepatotoxicity, thus paving the way for new therapeutic interventions.

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/content/journals/cpd/10.2174/0113816128338726241029175250
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Understanding and using Animal Models of Hepatotoxicity
Curr. Pharm. Des. 31, 943 (2025); https://doi.org/10.2174/0113816128338726241029175250
/content/journals/cpd/10.2174/0113816128338726241029175250
/content/journals/cpd/10.2174/0113816128338726241029175250
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  • Article Type:     Review Article
Keyword(s): fatty degeneration; free radicals; hepatic lesions; Hepatotoxicity; lipid peroxidation; nuclear pyknosis

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