Current Physical Chemistry - Volume 14, Issue 1, 2024

Polymorphism permits solids to have two or multiple crystal structures with varying orientations or conformations, and polymorph drug dissolution and solubility vary. Polymorphism influences drug efficacy, bioavailability and toxicity. Various parameters can regulate polymorph crystallization, including supersaturation phase, temperature, stirring rate, solvent addition rate, seed crystal, additives and pH. To characterize and mo Read More

Background: The aim of this research is to study the effect of length-to-width ratio on mesomorphism to enhance the understanding of its potential applications. This will be achieved by synthesizing a unique and innovative series of identical ester molecules, including lateral methoxy groups and terminal ethyl benzoate groups. In this research, we aim to find new insights into the relationship between molecular structures and me Read More

Background: The physicochemical properties, including the thermodynamics of micellization studies, received much attention. Cationic surfactant cetrimonium bromide (C16TABr) in electrolytes (sodium chloride and sodium salicylate) and nonelectrolyte (Ethylene glycol) in an aqueous solution were examined, and interesting results were obtained. The present investigation aims to identify a suitable combination of cationic surfa Read More

Aim: Potassium dihydrogen phosphate (KDP) is an excellent nonlinear optical material that has many potential applications, such as laser frequency conversion, Qswitches, Pockels cells, 3-D optical data storage devices, etc. Doping enhances various optical parameters of KDP. Doping changes in the absorbance and dopants such as aspartic acid, succinic acid, glycine, and L-alanine improved the optical band gap of the sample. Ba Read More

Background: The present work describes the synthesis, characterization, and thermo-acoustical parameters of binary solutions of 1-(2-(4-fluorophenyl)-5-(pyridin-4-yl)- 1,3,4-oxadiazol-3(2H)-yl)-3-(pyridin-2-yl)prop-2-en-1-one, (AS1-08) and 1-(2-(4- methoxyphenyl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl)-3-(pyridin-2-yl)prop-2-en-1- one, (AS1-12) in dimethyl sulfoxide (DMSO) and N, N-dimethylformamide (DMF) were esti Read More

Introduction: Remdesivir for injection is a Gilead Sciences manufactured drug product approved by the FDA to treat COVID-19. One of the critical attributes of this drug product, which is lyophilized, is its water moisture content. The current method used to determine the water content of remdesivir is the Karl Fischer titration method. The Karl Fischer method is considered the gold standard for determining the residual wat Read More