Current Physical Chemistry - Volume 12, Issue 3, 2022

Background: The chemical dependency caused by recreational drug abuse is highly detrimental to humans and has direct implications for society. Cannabis sativa is still at the top ranking of most used drugs in the world, and its major chemical component is Δ9-THC. This molecule is the main cause of addiction in chronic users, and its action is measured by the CB1 receptor present in the CNS. So far, there is no approved drug Read More

Background: Thiazoles are an important heterocycle that exhibit various bioactivities. Thiazole ring is found in the core structure of various medicinally useful compounds. It shows biological activities like anti-inflammatory, antibacterial, antifungal, antioxidant, cytotoxicity, anticonvulsant, insecticidal, anticancer and antitumor. Thioamides are reported to show bioactivities like antibacterial, antileukemia, antifungal, anti-arth Read More

Background: Anticancer activity of 9-anilinoacridine derivatives has been well reported. Although, the DNA-drug sequence-specific binding of these compounds may be affected by the substituent(s) on the aniline ring, it is still unclear which substituent (NH2 or CH2–OH) on the anilino ring of the compound is the critical element. A good understanding of chemical properties such as steric, lipophilic and electronic properties at the Read More

Background: Oxalate ligand-based metal complexes have long been used for the thermal synthesis of metal oxides. Polymeric homo/heterometallic oxalate-based molecular materials of the general formula, {A]MIIMIII[C2O4]3]}∞, [A = organic cation, MII/MIII: di/trivalent transition metal ion; C2O4: oxalate ligand] provides a molecular source to prepare metal oxides through solid state thermal decomposition primarily due to t Read More

Background: Pyridinium and imidazolium-based compounds show diverse applications with basic skeleton designs in order to achieve improved optical and thermal behavior. Aim: The aim of the study was to design and develop a greener, efficient protocol towards newer pyridinium and imidazolium compounds, and investigate optical, solvatochromic, thermal, and theoretical properties. Objectives: The purpose is to stud Read More

Background: Alzheimer’s disease (AD) has been characterized by a progressive loss of cognitive functions, especially memory, impacting the daily life and personality of the elderly. In the present study, we performed molecular modeling of methylxanthines and tannins, with pharmacologic actions as stimulants of the Central Nervous System (CNS) and antioxidant, respectively, present in Paullinia cupana Kunth (guarana), ev Read More