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Current Pharmaceutical Biotechnology - Online First
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The Biological Effects of Nano-curcumins against Drugs and Chemicals-Induced Nephrotoxicity: A Systematic Review
Available online: 30 April 2025More LessIntroduction/Objective Drug and chemical nephrotoxicity is a common cause of kidney disorders. This systematic review aimed to evaluate the recent progress in applying nano-curcumins (nano-CURs) to prevent and mitigate drug and chemical-induced nephrotoxicity, highlighting their underlying protective mechanisms and therapeutic potential. Methods A comprehensive search of experimental and clinical studies was Read More
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A Baicalin-targeted ZHX2/MMP14 Axis Attenuates Cirrhotic Portal
Authors: Hui Wang, Jiawei Ma, Jinghe Liu, Xiao Liu, Xiao Cai and Yufei ChangAvailable online: 24 April 2025More LessBackground Given the high mortality associated with Cirrhotic Portal Hypertension (CPH) worldwide, this study investigates the mechanism by which baicalin (BA), known for its beneficial effects on cirrhosis, alleviates CPH. Methods The CPH model was established in Sprague-Dawley (SD) rats, followed by 4-week oral administration of 30 and 60 mg/kg/day BA. SD rats were randomly assigned to four groups (n=6/group): Con, M Read More
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Anti-Cancer Properties and Mechanistic Insights of Dihydroquercetin
Authors: Cheng Zhang, Yuqiao Zeng, Bing Wu, Li Wang, Pengfei Wu, Ao Shen and Likun WangAvailable online: 24 April 2025More LessDihydroquercetin (DHQ), also known as taxifolin, is a naturally occurring flavonoid compound that serves as an active pharmaceutical ingredient. It is commercially available in the form of dietary supplements. As the reduced form of quercetin, DHQ contains five phenolic hydroxyl groups. This compound is capable of chelating transition metal ions, thereby effectively scavenging free radicals and detoxifying harmful substances Read More
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Selenium Alleviates Oxidative Stress and Inflammation to Promote Postpartum Uterine Recovery via GPX1/GPX4/NRF2 Pathway in Mice
Authors: Xiangping Li, Peng Li and Pingzhi WangAvailable online: 24 April 2025More LessBackground Selenium is an important trace element that plays crucial roles in metabolism, immune function, and antioxidant defense. As an antioxidant, selenium helps to alleviate postpartum uterine inflammation and promotes uterine recovery. However, the exact mechanism underlying the role of selenium in postpartum uterine recovery is not fully understood. Objective This study aimed to identify the underly Read More
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A Comprehensive 4-Layered In Silico Pharmacogenomics Analysis of the Genetic Addiction Risk Severity (GARS) Test: Strong Genetic Evidence Supporting GARS as a Novel Personalized Pre-Addiction Assessment Tool in the Opioid Crisis Era
Authors: Alireza Sharafshah, Kai-Uwe Lewandrowski, Igor Elman, David Baron, Panayotis K. Thanos, Colin Hanna, Mark S. Gold, Rajendra D. Badgaiyan, Jean Lud Cadet, Edward J. Modestino, Eric R. Braverman, Catherine A. Dennen, Milan Makale, Keerthy Sunder, Kevin T. Murphy, Abdalla Bowirrat, Albert Pinhasov, Marjorie Gondre-Lewis, Eliot Gardner, Daniel Sipple, Nicole Jafari, Foojan Zeine, Jag Khalsa, Rossano Kepler, Alvim Fiorelli and Kenneth BlumAvailable online: 16 April 2025More LessBackground Overdose involving opioids is the black heart of the addiction crisis. “Pre-addiction,” as an encouraging concept by NIDA and NIAAA, seems best captured with the construct of dopamine dysregulation. Referring to the abundant publications on “Reward Deficiency Syndrome” (RDS), Genetic Addiction Risk Score (GARS) test, RDSQ29, and KB220, Pre-addiction can be referred to as “reward dysregulation” as a su Read More
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Combating TB Pathology: Advanced Diagnostics, Innovative Therapies, and Public Health Strategies: A Review
Available online: 15 April 2025More LessTuberculosis (TB) continues to be a major global health challenge largely due to the complex nature of Mycobacterium tuberculosis. Its early detection and effective management are heavily reliant on advanced diagnostic methods. New drug delivery systems and repurposing existing drugs show great promise in improving TB treatment. This study explores the progress and hurdles in developing anti-TB drugs focusing Read More
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Molecular Mechanisms of Immune Resistance in Pancreatic Cancer: An Update
Authors: Wei Ming Pang, Wei Meng Lim, Zi Ni Ngai and Rhun Yian KohAvailable online: 15 April 2025More LessPancreatic cancer is an exceptionally aggressive form of cancer with a poor prognosis, primarily due to several factors, one of which is the significant development of immune resistance. Despite new medical perceptions of the interaction between the immune system and tumour, experts have continually explored the molecular mechanisms of immune resistance in pancreatic cancer over the years but have not ye Read More
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Interaction Between Staphylococcus aureus and Microbiota: Invasion or Commensalism
Authors: Ahmad Nasser and Shiva JahanbakhshiAvailable online: 14 April 2025More LessThe term “Microbiota” refers to the vast array of symbiotic microorganisms that coexist with their hosts in practically all organs. However, the microbiota must obtain nutrition and minerals from its host to survive; instead, they produce beneficial compounds to protect the host and regulate the immune system. Conversely, pathogenic bacteria utilize their enzymes to independently gain sustenance through an invasive proces Read More
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Protective Role of Coffee in Thioacetamide-induced Nephrotoxicity: A Study in Rats
Available online: 09 April 2025More LessObjectiveThe purpose of the present research was to assess the protective role of coffee in thioacetamide-induced nephrotoxicity.MethodsThe experimental period consisted of 18 weeks, divided into two phases. Four experimental groups were designed, each consisting of six rats. Group I was considered an untreated control group. Groups II and III were intraperitoneally injected with thioacetamide at a dose of 200 mg/kg Read More
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Bioactive Phytochemicals: Unlocking the Promise of Natural Remedies for Diabetes Mellitus
Authors: Diksha Gulati, Ajmer Singh Grewal and Balraj SainiAvailable online: 03 April 2025More LessBackground Metabolic syndrome encompasses conditions such as diabetes mellitus (DM), which has become increasingly prevalent. Chemically synthesized medications are commonly used to mitigate the effects of DM and its complications; however, these often result in undesirable side effects, including weight gain, digestive issues, and heart failure. Objective This review highlights the therapeutic potential of bioactive c Read More
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Unraveling the Mechanism of Tangmaikang Granules in Treating Diabetic Kidney Disease Based On UPLC-MS/MS, Network Pharmacology, Molecular Docking, Molecular Dynamics Simulations, and Experimental Validation
Authors: Zhixin Wang, Shuqin Liu, Ying Zhang, Huaming Xian, Xinzhu Yuan, Changwei Lin and Xisheng XieAvailable online: 27 March 2025More LessBackground Diabetic Kidney Disease (DKD) is a major cause of End-Stage Renal Disease (ESRD) and lacks effective treatments. Tangmaikang Granules (TMK), a multi-herb traditional Chinese medicine formulation, have shown potential in managing DKD. However, the precise active components, molecular mechanisms, and therapeutic advantages of TMK remain unclear. Objective This study tests the hypothesis that Read More
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Tumor Image Segmentation: A Bibliometric Analysis from 2003 to Now
Authors: Zhenghao Chen, Zhongqing Wang and He MaAvailable online: 19 March 2025More LessBackground Bibliometrics has been applied to the study of tumor image segmentation, which can indicate the current research hotspots and trends. Methods In this study, bibliometric analyses were performed on data retrieved from the Web of Science database. A total of 3,377 articles on the application of tumor image segmentation from January 1, 2003, to October 9, 2024, were analyzed for the characteristics of the Read More
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Recent Advancements in Nanoparticles-based Approaches for the Theranostics of Glioblastoma Multiforme
Authors: Jugal Mandan and Abhishek KanugoAvailable online: 18 March 2025More LessOne of the deadliest and most challenging tumors in the body is Glioblastoma Multiforme (GBM). The Most aggressive kinds of brain tumors pose multiple challenges in their treatment due to several barriers (BBB and BCSF). Conventional treatments show poor efficacy in the treatment owing to poor penetrability through the blood-brain barrier and extreme toxicity in the brain. Moreover, the prognosis and diagnosis of GBM ar Read More
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Construction and Validation of T‐cell Exhaustion‐related Gene Signature for Predicting Prognosis in Diffuse Large B-cell Lymphoma
Authors: Lixin Lv, Jie Zhou and Aibin LiangAvailable online: 18 March 2025More LessBackground T-cell exhaustion (TEX) is one reason for immunotherapy resistance among cancers, but the specific mechanism and influencing factors of TEX in diffuse large B-cell lymphoma (DLBCL) are not fully understood. This study aimed to establish a TEX signature for predicting the prognosis of DLBCL and investigate the immune characteristics related to the TEX signature. Methods The gene expression data of DLB Read More
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Progress and Application of Multifunctional Ultrasound Theranostic Agents
Authors: Kejing Fang, Jincan Lei, Yi Zhao, Yujie Feng, Haiyun Huang and Changjun HouAvailable online: 07 March 2025More LessUltrasound is an indispensable technology in the biomedical field. With the continuous integration and development of ultrasound medical technology, its potential application value in disease diagnosis and treatment has become increasingly prominent. As the technical core, novel multifunctional ultrasound theranostic agents have been the main focus of research. Here, we summarized various types of multifunctio Read More
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In-vitro, In-vivo and Molecular Docking Studies on Dietary Supplement Containing Polar and Non-polar fractions of Persea Americana for Management of Diet-related Chronic Diseases
Authors: Doha A. Mohamed, Gamil Ibrahim, Hoda B. Mabrok and Ibrahim HamedAvailable online: 05 March 2025More LessBackground Diet-related chronic diseases, such as cardiovascular diseases, obesity, diabetes, autoimmune diseases and cancer, are largely preventable with a healthy diet and lifestyle. Therefore, searching for dietary supplements rich in antioxidant and anti-inflammatory phytochemicals for the prevention and/or management of diet-related chronic diseases is an important strategy for controlling these dis Read More
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In vitro Antibiofilm Activity-directed In silico Identification of Natural Products Targeting Bacterial Biofilm Regulators SarA and LasR
Available online: 18 February 2025More LessBackground Antibiofilm agents serve as an essential tool in the fight against antibiotic resistance, and natural products provide a promising source for potential drug leads. Objective This study investigates the activity of twenty Bangladeshi medicinal plants against Staphylococcus aureus and Pseudomonas aeruginosa biofilms and predicts the interactions of selected phytochemicals from five of the best performing plants with Read More
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The Role of Immunosenescence and Inflammaging in the Susceptibility of Older Adults to SARS-CoV-2 Infection
Available online: 13 February 2025More LessCOVID-19 is an ongoing pandemic caused by the SARS-CoV-2 coronavirus that is one of the most significant challenges to public health over the past few years. Most people are vulnerable to SARS-CoV-2, but older adults are more vulnerable. Aging is one of the major risk factors for the detrimental consequences of COVID-19, likely due to chronic inflammation and immunosenescence, both of which are the characteristic Read More
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Research on Neuroimmune Gastrointestinal Diseases Based on Artificial Intelligence: Molecular Dynamics Analysis of Caffeine and DRD3 Protein
Authors: Yi Qin, Shuran Huo, Ana María González, Lizhong Guo, Javier Sanots and Liangyu LiAvailable online: 04 February 2025More LessObjective The aim of this study was to develop a clinical application model for the rational use of caffeine. Background Caffeine is related to the incidence of neuro immune gastrointestinal diseases. Coffee consumption needs to be optimized in order to reduce the incidence rate. Purpose By using KEEG analysis to explore potential molecular signaling pathways involved in the progression of neurological immune gastrointestin Read More
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HYQTD Drug-containing Serum Alleviates H2O2-induced Endothelial Oxidative Damage by Increasing Mitochondrial ATP Synthesis and Inhibiting ROS
Authors: Jin Wu, Lijuan Chen, Ying Du, Xue Leng, Dongchao Yuan, Mingqian Yang, Yeyu Zhao, Bin Lv and Lianqun JiaAvailable online: 27 January 2025More LessBackground Atherosclerosis (AS) is caused by the endothelium injury associated with oxidative stress. Previous studies have shown that the Phlegm-Eliminating and Stasis-Transforming Decoction (Huayu Qutan Decoction, HYQTD) has mitochondrial protective function. The objective of this research was to explore how HYQTD drug-containing serum (HYQTD-DS) could potentially protect mitochondrial energy production in en Read More
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