Current Pharmaceutical Biotechnology - Online First

Background Psoriasis is a chronic skin disease that affects patients' quality of life. Treating psoriasis remains a significant challenge due to various factors, including individual response variability, drug resistance, and the range of side effects associated with currently available medications. Nowadays, numerous research efforts are being made aiming at overcoming the obstacles of the available psoriasis treatments are still Read More

Objective To predict and assist in the treatment of colorectal cancer. Background Precision medicine systems can provide strategy optimization for the diagnosis and treatment of colorectal cancer to meet the needs of clinical pricing institutions. Aim To design an artificial intelligence multimodal gastrointestinal disease clinical information system based on neuroimmune gene regulation. Methods The system includes the use of cel Read More

Background Given the high mortality associated with Cirrhotic Portal Hypertension (CPH) worldwide, this study investigates the mechanism by which baicalin (BA), known for its beneficial effects on cirrhosis, alleviates CPH. Methods The CPH model was established in Sprague-Dawley (SD) rats, followed by 4-week oral administration of 30 and 60 mg/kg/day BA. SD rats were randomly assigned to four groups (n=6/group): Con, M Read More

Background Selenium is an important trace element that plays crucial roles in metabolism, immune function, and antioxidant defense. As an antioxidant, selenium helps to alleviate postpartum uterine inflammation and promotes uterine recovery. However, the exact mechanism underlying the role of selenium in postpartum uterine recovery is not fully understood. Objective This study aimed to identify the underly Read More

Background Overdose involving opioids is the black heart of the addiction crisis. “Pre-addiction,” as an encouraging concept by NIDA and NIAAA, seems best captured with the construct of dopamine dysregulation. Referring to the abundant publications on “Reward Deficiency Syndrome” (RDS), Genetic Addiction Risk Score (GARS) test, RDSQ29, and KB220, Pre-addiction can be referred to as “reward dysregulation” as a su Read More

Pancreatic cancer is an exceptionally aggressive form of cancer with a poor prognosis, primarily due to several factors, one of which is the significant development of immune resistance. Despite new medical perceptions of the interaction between the immune system and tumour, experts have continually explored the molecular mechanisms of immune resistance in pancreatic cancer over the years but have not ye Read More

ObjectiveThe purpose of the present research was to assess the protective role of coffee in thioacetamide-induced nephrotoxicity.MethodsThe experimental period consisted of 18 weeks, divided into two phases. Four experimental groups were designed, each consisting of six rats. Group I was considered an untreated control group. Groups II and III were intraperitoneally injected with thioacetamide at a dose of 200 mg/kg Read More

Background Diabetic Kidney Disease (DKD) is a major cause of End-Stage Renal Disease (ESRD) and lacks effective treatments. Tangmaikang Granules (TMK), a multi-herb traditional Chinese medicine formulation, have shown potential in managing DKD. However, the precise active components, molecular mechanisms, and therapeutic advantages of TMK remain unclear. Objective This study tests the hypothesis that Read More

One of the deadliest and most challenging tumors in the body is Glioblastoma Multiforme (GBM). The Most aggressive kinds of brain tumors pose multiple challenges in their treatment due to several barriers (BBB and BCSF). Conventional treatments show poor efficacy in the treatment owing to poor penetrability through the blood-brain barrier and extreme toxicity in the brain. Moreover, the prognosis and diagnosis of GBM ar Read More

Ultrasound is an indispensable technology in the biomedical field. With the continuous integration and development of ultrasound medical technology, its potential application value in disease diagnosis and treatment has become increasingly prominent. As the technical core, novel multifunctional ultrasound theranostic agents have been the main focus of research. Here, we summarized various types of multifunctio Read More