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Current Pharmaceutical Biotechnology - Online First
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Antifungal Resistance in Vaginal Candidiasis Among Reproductive-age Women: A Review
Available online: 08 May 2025More LessCandida is a type of fungus that can cause infections in humans. Sometimes, these infections become tough to treat because the Candida fungus resists antifungal drugs. This resistance depends on both the specific type of Candida and how it interacts with the human body. For instance, Candida can change its genetic makeup or produce proteins that pump out the drugs, making them less effective. Additionally, Candida Read More
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Optimization and Characterization of Khellin Loaded Nanogels for the Potential Use in Psoriasis Management
Available online: 05 May 2025More LessBackground Psoriasis is a chronic skin disease that affects patients' quality of life. Treating psoriasis remains a significant challenge due to various factors, including individual response variability, drug resistance, and the range of side effects associated with currently available medications. Nowadays, numerous research efforts are being made aiming at overcoming the obstacles of the available psoriasis treatments are still Read More
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The Biological Effects of Nano-curcumins against Drugs and Chemicals-Induced Nephrotoxicity: A Systematic Review
Available online: 30 April 2025More LessIntroduction/Objective Drug and chemical nephrotoxicity is a common cause of kidney disorders. This systematic review aimed to evaluate the recent progress in applying nano-curcumins (nano-CURs) to prevent and mitigate drug and chemical-induced nephrotoxicity, highlighting their underlying protective mechanisms and therapeutic potential. Methods A comprehensive search of experimental and clinical studies was Read More
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Clinical Diagnosis and Treatment System for Neurological Psychological Gastrointestinal Diseases Based on Multimodal Artificial Intelligence and Immunology
Authors: Liangyu Li, Jun Jiang, Lizhong Guo, Javier Santos, Ana María González, Siyi Li and Yi QinAvailable online: 29 April 2025More LessObjective To predict and assist in the treatment of colorectal cancer. Background Precision medicine systems can provide strategy optimization for the diagnosis and treatment of colorectal cancer to meet the needs of clinical pricing institutions. Aim To design an artificial intelligence multimodal gastrointestinal disease clinical information system based on neuroimmune gene regulation. Methods The system includes the use of cel Read More
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Sirtuins in Osteosarcoma: Cracking the Code and Opening Up New Treatment Options
Authors: Yushi Zhao, Yong Han, Baichuan Wang and Ting WangAvailable online: 25 April 2025More LessOsteosarcoma (OS) is a frequent primary malignant bone tumor that primarily affects adolescents and the elderly, and it is prone to metastasis and recurrence. The prognostic status of metastatic and recurrent OS has remained stagnant over the past decades despite the availability of an extensive range of chemotherapy drugs in the clinic. To increase the overall survival and quality of life of patients with osteosarcoma, ne Read More
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A Baicalin-targeted ZHX2/MMP14 Axis Attenuates Cirrhotic Portal
Authors: Hui Wang, Jiawei Ma, Jinghe Liu, Xiao Liu, Xiao Cai and Yufei ChangAvailable online: 24 April 2025More LessBackground Given the high mortality associated with Cirrhotic Portal Hypertension (CPH) worldwide, this study investigates the mechanism by which baicalin (BA), known for its beneficial effects on cirrhosis, alleviates CPH. Methods The CPH model was established in Sprague-Dawley (SD) rats, followed by 4-week oral administration of 30 and 60 mg/kg/day BA. SD rats were randomly assigned to four groups (n=6/group): Con, M Read More
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Anti-Cancer Properties and Mechanistic Insights of Dihydroquercetin
Authors: Cheng Zhang, Yuqiao Zeng, Bing Wu, Li Wang, Pengfei Wu, Ao Shen and Likun WangAvailable online: 24 April 2025More LessDihydroquercetin (DHQ), also known as taxifolin, is a naturally occurring flavonoid compound that serves as an active pharmaceutical ingredient. It is commercially available in the form of dietary supplements. As the reduced form of quercetin, DHQ contains five phenolic hydroxyl groups. This compound is capable of chelating transition metal ions, thereby effectively scavenging free radicals and detoxifying harmful substances Read More
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Selenium Alleviates Oxidative Stress and Inflammation to Promote Postpartum Uterine Recovery via GPX1/GPX4/NRF2 Pathway in Mice
Authors: Xiangping Li, Peng Li and Pingzhi WangAvailable online: 24 April 2025More LessBackground Selenium is an important trace element that plays crucial roles in metabolism, immune function, and antioxidant defense. As an antioxidant, selenium helps to alleviate postpartum uterine inflammation and promotes uterine recovery. However, the exact mechanism underlying the role of selenium in postpartum uterine recovery is not fully understood. Objective This study aimed to identify the underly Read More
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Challenges and Pathways in Regulating Next-Gen Biological Therapies
Authors: Surendra Agrawal, Sunita Vaidya, Jitendra Patel, Pranita Jirvankar and Pravina GurjarAvailable online: 23 April 2025More LessBackground Current medicine could benefit from gene and cell therapies for genetic defects, cancer, and degenerative disorders. These therapies modify genetic material or biological components. CRISPR-Cas9 gene editing, stem cell, and CAR-T treatments are examples. Complex products need rigorous regulations to ensure quality, efficacy, and patient safety. Objectives This paper discusses international gene and cell-base Read More
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A Comprehensive 4-Layered In Silico Pharmacogenomics Analysis of the Genetic Addiction Risk Severity (GARS) Test: Strong Genetic Evidence Supporting GARS as a Novel Personalized Pre-Addiction Assessment Tool in the Opioid Crisis Era
Authors: Alireza Sharafshah, Kai-Uwe Lewandrowski, Igor Elman, David Baron, Panayotis K. Thanos, Colin Hanna, Mark S. Gold, Rajendra D. Badgaiyan, Jean Lud Cadet, Edward J. Modestino, Eric R. Braverman, Catherine A. Dennen, Milan Makale, Keerthy Sunder, Kevin T. Murphy, Abdalla Bowirrat, Albert Pinhasov, Marjorie Gondre-Lewis, Eliot Gardner, Daniel Sipple, Nicole Jafari, Foojan Zeine, Jag Khalsa, Rossano Kepler, Alvim Fiorelli and Kenneth BlumAvailable online: 16 April 2025More LessBackground Overdose involving opioids is the black heart of the addiction crisis. “Pre-addiction,” as an encouraging concept by NIDA and NIAAA, seems best captured with the construct of dopamine dysregulation. Referring to the abundant publications on “Reward Deficiency Syndrome” (RDS), Genetic Addiction Risk Score (GARS) test, RDSQ29, and KB220, Pre-addiction can be referred to as “reward dysregulation” as a su Read More
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Combating TB Pathology: Advanced Diagnostics, Innovative Therapies, and Public Health Strategies: A Review
Available online: 15 April 2025More LessTuberculosis (TB) continues to be a major global health challenge largely due to the complex nature of Mycobacterium tuberculosis. Its early detection and effective management are heavily reliant on advanced diagnostic methods. New drug delivery systems and repurposing existing drugs show great promise in improving TB treatment. This study explores the progress and hurdles in developing anti-TB drugs focusing Read More
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Molecular Mechanisms of Immune Resistance in Pancreatic Cancer: An Update
Authors: Wei Ming Pang, Wei Meng Lim, Zi Ni Ngai and Rhun Yian KohAvailable online: 15 April 2025More LessPancreatic cancer is an exceptionally aggressive form of cancer with a poor prognosis, primarily due to several factors, one of which is the significant development of immune resistance. Despite new medical perceptions of the interaction between the immune system and tumour, experts have continually explored the molecular mechanisms of immune resistance in pancreatic cancer over the years but have not ye Read More
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Interaction Between Staphylococcus aureus and Microbiota: Invasion or Commensalism
Authors: Ahmad Nasser and Shiva JahanbakhshiAvailable online: 14 April 2025More LessThe term “Microbiota” refers to the vast array of symbiotic microorganisms that coexist with their hosts in practically all organs. However, the microbiota must obtain nutrition and minerals from its host to survive; instead, they produce beneficial compounds to protect the host and regulate the immune system. Conversely, pathogenic bacteria utilize their enzymes to independently gain sustenance through an invasive proces Read More
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Protective Role of Coffee in Thioacetamide-induced Nephrotoxicity: A Study in Rats
Available online: 09 April 2025More LessObjectiveThe purpose of the present research was to assess the protective role of coffee in thioacetamide-induced nephrotoxicity.MethodsThe experimental period consisted of 18 weeks, divided into two phases. Four experimental groups were designed, each consisting of six rats. Group I was considered an untreated control group. Groups II and III were intraperitoneally injected with thioacetamide at a dose of 200 mg/kg Read More
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Bioactive Phytochemicals: Unlocking the Promise of Natural Remedies for Diabetes Mellitus
Authors: Diksha Gulati, Ajmer Singh Grewal and Balraj SainiAvailable online: 03 April 2025More LessBackground Metabolic syndrome encompasses conditions such as diabetes mellitus (DM), which has become increasingly prevalent. Chemically synthesized medications are commonly used to mitigate the effects of DM and its complications; however, these often result in undesirable side effects, including weight gain, digestive issues, and heart failure. Objective This review highlights the therapeutic potential of bioactive c Read More
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Unraveling the Mechanism of Tangmaikang Granules in Treating Diabetic Kidney Disease Based On UPLC-MS/MS, Network Pharmacology, Molecular Docking, Molecular Dynamics Simulations, and Experimental Validation
Authors: Zhixin Wang, Shuqin Liu, Ying Zhang, Huaming Xian, Xinzhu Yuan, Changwei Lin and Xisheng XieAvailable online: 27 March 2025More LessBackground Diabetic Kidney Disease (DKD) is a major cause of End-Stage Renal Disease (ESRD) and lacks effective treatments. Tangmaikang Granules (TMK), a multi-herb traditional Chinese medicine formulation, have shown potential in managing DKD. However, the precise active components, molecular mechanisms, and therapeutic advantages of TMK remain unclear. Objective This study tests the hypothesis that Read More
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Tumor Image Segmentation: A Bibliometric Analysis from 2003 to Now
Authors: Zhenghao Chen, Zhongqing Wang and He MaAvailable online: 19 March 2025More LessBackground Bibliometrics has been applied to the study of tumor image segmentation, which can indicate the current research hotspots and trends. Methods In this study, bibliometric analyses were performed on data retrieved from the Web of Science database. A total of 3,377 articles on the application of tumor image segmentation from January 1, 2003, to October 9, 2024, were analyzed for the characteristics of the Read More
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Recent Advancements in Nanoparticles-based Approaches for the Theranostics of Glioblastoma Multiforme
Authors: Jugal Mandan and Abhishek KanugoAvailable online: 18 March 2025More LessOne of the deadliest and most challenging tumors in the body is Glioblastoma Multiforme (GBM). The Most aggressive kinds of brain tumors pose multiple challenges in their treatment due to several barriers (BBB and BCSF). Conventional treatments show poor efficacy in the treatment owing to poor penetrability through the blood-brain barrier and extreme toxicity in the brain. Moreover, the prognosis and diagnosis of GBM ar Read More
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Construction and Validation of T‐cell Exhaustion‐related Gene Signature for Predicting Prognosis in Diffuse Large B-cell Lymphoma
Authors: Lixin Lv, Jie Zhou and Aibin LiangAvailable online: 18 March 2025More LessBackground T-cell exhaustion (TEX) is one reason for immunotherapy resistance among cancers, but the specific mechanism and influencing factors of TEX in diffuse large B-cell lymphoma (DLBCL) are not fully understood. This study aimed to establish a TEX signature for predicting the prognosis of DLBCL and investigate the immune characteristics related to the TEX signature. Methods The gene expression data of DLB Read More
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Progress and Application of Multifunctional Ultrasound Theranostic Agents
Authors: Kejing Fang, Jincan Lei, Yi Zhao, Yujie Feng, Haiyun Huang and Changjun HouAvailable online: 07 March 2025More LessUltrasound is an indispensable technology in the biomedical field. With the continuous integration and development of ultrasound medical technology, its potential application value in disease diagnosis and treatment has become increasingly prominent. As the technical core, novel multifunctional ultrasound theranostic agents have been the main focus of research. Here, we summarized various types of multifunctio Read More
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