Current Pharmaceutical Biotechnology - Volume 8, Issue 5, 2007

Adaptation of marine bacteria to the harsh environments has led to a rich biological and genetic diversity. Marine bacteria are attracting attention as new biotechnological resources. These bacteria can be a potential source of new bioactive compounds for industrial, agricultural, environmental, pharmaceutical and medical uses. The present paper reveals the potential of the marine bacteria with biotechnological applications rela Read More

Reentries of a single molecule in the confocal, femtoliter-sized probe region (about 10-16 L and less) are significant because during measurement times they give rise to fluctuation phenomena such as molecule number fluctuations at the single-molecule level in solution without immobilization or hydrodynamic focusing. These fluctuations are the fundamental physical process on which, for example, fluorescence correlation spe Read More

In the last 20 years the practice of DNA sequence detection has gained more and more importance in a variety of fields like-genetics, food safety, pathology, and criminology. This has been driven by the growing knowledge about the human and other organism's genome. The development of sophisticated technologies for the analysis of DNA makes the analysis of DNA faster and easier to use, and enable numerous researcher Read More

Among the methods for single molecule detection in the field of medicinal chemistry, the importance of fluorescence correlation spectroscopy (FCS) is growing. FCS has the advantage of permitting us to determine the number of fluorescent molecules and the diffusion constant dependent on the molecular weight without any physical separation process such as gel electrophoresis. Thus this method is appropriate for studies Read More

This review deals with the antisense technology that, together, forms a very powerful tool to inhibit gene expression and may be used for studying gene function (functional genomics) and for therapeutic purpose (antisense gene therapy). Antisense oligonucleotides block translation of target mRNAs in a sequence specific manner, either by steric blocking of translation or by destruction of the bound mRNA via RNase-H enzyme Read More

Cellular therapies derived from embryonic stem (ES) cells have gained a renewed interest with the experimental demonstration that an embryonic stem cell lines can be established from human blastocyst-stage embryos and prompted to differentiate into almost all types of cells present in the body including hematopoietic cells. Hematopoiesis is a series of cellular processes whereby short-lived mature blood cells are continuou Read More