Current Pharmaceutical Biotechnology - Volume 18, Issue 11, 2017

Background: Skin is the largest and most visible organ of the body. Many of its functions include temperature regulation, immunity from microorganisms, maintaining electrolyte balance, and protection from physical injuries, chemical agents and ultraviolet (UV) radiation. Aging occurs in every layer of the skin, primarily due to the degradation of its components. Induction of degradative enzymes and the abundant prod Read More

Background: High flow nasal cannula (HFNC) is widely utilized to support critically ill adults, pediatrics and neonates. Through the continuous delivery of oxygen at high flow rates that meet or exceed patients' inspiratory flow, HFNC improves oxygenation, respiratory rates, patient comfort, and tolerance during therapy. As HFNC becomes more widely employed, clinicians have started to consider aerosol drug delivery throug Read More

Background: Health benefits, including immune modulating capability, exerted by Bifidobacterium strains have been attributed to their exopolysaccharides (EPSs). Objective: The effects of the purified EPS from B. longum W11 on cytokine production by peripheral blood mononuclear cells (PBMCs) alone or ConA-stimulated were investigated. Method: The production of IFN-γ, IL-1β, IL-6 and IL-10 by PBMCs from healthy Read More

Background: The starting point for the development of new, functional products derived from Rubus fruticosus L. is to determine the optimal cultivation conditions that produce maximal yield of fruits containing desirable bioactive properties. Towards that goal, the effect of soil, soil/peat mixture and light intensity on the nutraceutical and cosmeceutical potential of two cultivars (‘Thornfree’ and ‘Loch Ness’) of Rubus frutic Read More

Background: Recently, the development of a safe bioactive material with antioxidant properties, which can improve healing activity are focusing. Biosurfactants are very famous for their antimicrobial and free radical scavenging activities. Thereof, the main aim of the present study was to investigate the antioxidant and wound healing activity of the lipopeptide biosurfactant (LBS) produced by Acinetobacter junii B6. DPPH r Read More

Background: Biopolymers based materials (polysaccharides, lipids, proteins, and nucleic acids) are one of the basic resources in bio-engineering sciences because of desirable features. Moreover, nanobiotechnology innovates nanomaterial and associated technique in nano medicine (drug delivery and tissue engineering). Methods: In the nano-medicine, fibers are introduced as a successful biomimetic extracellular matrix s Read More

Objective: In this research, fatty acid profile and polyphenolic content of an ethanolic extract of walnut from Juglans regia L. collected in Central Italy, were characterized. The potential antioxidant and anti-inflammatory effects of the extract were investigated in the human keratinocytes cell line. Methods: Fatty acid profile was determined by gas chromatography/mass spectrometry analysis, total phenolic content by Folin-Cio Read More

Objective: Optimization of the medium for recombinant arginine deiminase production in E. coli was performed using response surface methodology. This is the first study of optimization of recombinant arginine deiminase production in E. coli by the use of response surface methodology. Methods: A Mycoplasm arginine deiminase gene was computationally optimized and inserted into pET-3a (+) expression v Read More