Current Pharmaceutical Biotechnology - Volume 16, Issue 3, 2015

Inflammatory bowel disease (IBD) is an idiopathic chronic, relapsing inflammation of the bowel which is caused by dysregulation of the mucosal immune system. Polyphenols as the secondary plant metabolites universally present in vegetables and fruits and are the most abundant antioxidants in the human diet. There is evidence demonstrating the beneficial health effects of dietary polyphenols. This review criticize Read More

Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease that occurs throughout the world with no racial, ethnic or socioeconomic boundaries. Despite its high morbidity and mortality, there are limited medications available for ALS that may increase survival in patients with amyotrophic lateral sclerosis by approximately 2-3 months. Inasmuch as negative effects of riluzole on muscle atrophy and wasting, we Read More

Lots of epidemiological studies have put forward the beneficial effects of dietary polyphenols consumption in the prevention of diseases related to aging i.e vascular pathologies, neurodegeneration, cancers and associated inflammatory processes. Among polyphenols, resveratrol (trans-3,4’,5- trihydroxystilbene, RSV), a naturally occurring stilbene widely distributed in foodstuffs such as grapes and wine, has been the most studi Read More

Atherosclerosis is a multifactorial disease mainly caused by deposition of low-density lipoprotein (LD) cholesterol in macrophages of arterial walls. Atherosclerosis leads to heart attacks as well as stroke. Epidemiological studies showed that there is an inverse correlation between fruit and vegetable consumption and the risk of atherosclerosis. The promising effect of high vegetable and fruit containing diet on atherosclerosi Read More

Dual action of galanthamine as potent cholinesterase inhibitor and nicotinic modulator has attracted a great attention to be used in the treatment of AD. Consequently, galanthamine, a natural alkaloid isolated from a Galanthus species (snowdrop, Amaryllidaceae), has become an attractive model compound for synthesis of its novel derivatives to discover new drug candidates. Numerous studies have been done to elucidate i Read More

Polyphenols are an extensive group of substances present in plants. Animals and humans achieve them through the diet. Polyphenols have been related to several processes, such as oxidative stress and signaling pathways modulating gene expression that promote an anti-inflammatory environment. Moreover, polyphenols also have a possible role in the protection of several diseases, including major depression. Depressi Read More

Black, green, and white teas are the main commercial teas obtained from buds and leaves of Camellia sinensis (L.). The postharvest processing treatments, together with genotype and growing techniques, may strongly affect the chemical composition of the tea infusion and, thereby, its potential effects on health. Catechins constituted up to 30% of tea leaves dry weight. During fermentation, polyphenols undergo enzyma Read More

Biological effects of natural polyphenols from mango and their potential impact on human health have become of increasing interest. The occurrence of glycosilated molecules, such as mangiferin (C2-β-Dglucopyranosyl- 1,3,6,7-tetrahydroxyxanthone), main component of the mango polyphenolic fraction, and benzophenones, flavonoids (catechin and epicatechin), phenolic acids (benzoic and gallic), and a wide range o Read More

Premature ejaculation (PE) is an important and common sexual issue in male adults, since its etiology is still unknown. There are many suggested treatments such as paroxetine, clomipramine, dapoxetine, tramadol and topical agents; all of them have stigma or considerable side effects. Therefore, present study aimed to examine the effect of on-demand caffeine consumption on treating patients with PE. In this double bli Read More