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2000
Volume 22, Issue 11
  • ISSN: 1389-2010
  • E-ISSN: 1873-4316

Abstract

Background: γ-Poly-Glutamic Acid (γ-PGA) is a naturally occurring homo-polyamide produced by various strains of Bacillus. It is made from repeating units of L-glutamic acid, D-glutamic acid, or both connected through amide linkages between α-amino and γ-carboxylic acid groups. As a biopolymer substance, the attractive properties of γ-PGA are that it is water-soluble, biodegradable, biocompatible, non-toxic, non-immunogenic, and edible. Therefore, it can be used as a green and environmentally friendly biological material. Methods: The review concentrates on the reports revealing the functions and potential use of γ-PGA and its derivatives in medicine. Results & Discussion: γ-PGA is described to possess several properties that may be exploited in medicine. The biopolymer reportedly has been successfully applied not only as a metal chelator, drug carrier/ deliverer, and gene vector, but also used safely as a vaccine adjuvant, tissue engineering material, and contrast agent. Conclusion: γ-PGA could be potentially considered as a potential biomedical material in the field of medicine.

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/content/journals/cpb/10.2174/1389201021999201118161155
2021-09-01
2025-07-07
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  • Article Type:
    Review Article
Keyword(s): application; biological material; biopolymer; function; medicine; γ-Poly-glutamic acid
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