Current Pharmaceutical Analysis - Volume 9, Issue 3, 2013

Ibandronate is a potent nitrogen-containing bisphosphonate with a tertiary amine group, which does not easily form chromophore derivatives that can be detected by UV light of fluorescence emission. Here, a simple and straightforward automated multicommutated flow system, making use of water-soluble mercaptopropionic acid-capped CdTe quantum dots, was implemented for the fluorescence quantitation of ibandronate in Read More

The present study proposes an agar diffusion microbiological assay for quantitation of the antibiotic doripenem in powder for injection. The method was developed according to official guidelines and its stability-indicating performance was studied by stress testing in pre-defined conditions of heat and UV-C radiation. Based on the response obtained from growth inhibition of a strain of Staphylococcus epidermidis ATCC 12228, the q Read More

The aim of this study was to investigate the effects of ionizing radiation on the physicochemical properties of four excipients used in pharmaceutical technology (microcrystalline cellulose, methylcellulose, hydroxyethylcellulose and hydroxypropyl methylcellulose) with the view of using ionizing radiation for their sterilization. A number of analytical methods (FT-IR, XRD, TG,CPMAS NMR and measurements of pH and viscosity) wer Read More

The state-of-the-art and possibilities offered by derivative spectrophotometry in the field of pharmaceutical analysis during the period 2008 - 2012 are reviewed. This paper draws attention to the fact that derivative treatment continues to be a promising tool for analysis of spectra composed of unresolved bands as it provides selective, validated, simple and cost effective analytical methods.

Quinapril undergoes a significant degradation in the solid state, specially in the presence of humidity, temperature and pharmaceutical excipients. Since dissolution increases the degradation, hydrolytic reactions are among the most common processes involved in drug degradation. Improving the knowledge regarding drug stability, particularly concerning the critical factors that can influence the stability of the active substance Read More

The electrochemical behavior of sotalol was investigated on a graphene oxide nanosheets-modified glassy carbon electrode in a phosphate buffer solution, pH 7.4. Cyclic voltammetry and chronoamperometry were employed to obtain information about the electrooxidation process. During the electrooxidation of sotalol, one irreversible anodic peak appeared in the voltammograms. Some kinetic parameters, such as the diffusio Read More

Levodropropizine is a cough suppressant and easily oxidizable at the carbon-base electrodes. The electrooxidative behavior and determination of levodropropizine on glassy carbon and boron-doped diamond electrodes were investigated using cyclic, linear sweep, differential pulse, and square wave voltammetric methods. The dependence of the peak current and peak potentials on pH, concentration, nature of the buffer, and s Read More

Azithromycin dihydrate is a semi-synthetic macrolide antibiotic drug, effective against a wide variety of bacteria. It is primarily used to treat the bacterial infections associated with weaker immune system. A simple, accurate, rapid and cost effective spectrometric method for the estimation of azithromycin has been developed and validated by the acidic hydrolysis of the drug with sulphuric acid and monitoring the absorbanc Read More

This paper describes the development and validation of a most economical and sensitive isocratic stability indicating HPLC method for the assay of recombinant human insulin (RHI) from yeast origin (Hansenula polymorpha). The method employs a Thermo Biobasic, C-18 (250 x 4.6 mm, 300 A°, 5 µm) column with a mobile phase of acetonitrile - potassium dihydrogen phosphate ( pH 2.5; 50 mM) (35:65, v/v) and UV detection at 2 Read More