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- Volume 7, Issue 4, 2011
Current Pharmaceutical Analysis - Volume 7, Issue 4, 2011
Volume 7, Issue 4, 2011
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Recent Advances in Stability Studies of Carbapenems
More LessThe carbapenems are a class of a β-lactam antibiotics with a broad spectrum of antibacterial activity. In all carbapenems, a β-lactam ring is required for their antibacterial activity. In addition, the bi-cyclic 4:5 fused ring is one of the main reasons for the instability of carbapenems. The 2C, 3C and 6C substituents affect the spectrum of microbiological activity, pharmacokinetic parameters, enzymatic and chemical stability. T Read More
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Development and Validation of a Liquid-Liquid Extraction and Gas Chromatography/Mass Spectrometry Methodology for Cannabidiol Analysis in Human Plasma
Cannabidiol (CBD) is a cannabinoid found in the Cannabis sativa plant and it is devoid of the typical cognitive and psychological effects of Delta 9-tetrahydrocannabinol (Delta 9-THC). However, studies with animals suggest that CBD presents anxiolytic properties. In the face of evidence of a cannabinoid system in humans, and the growing interest in the therapeutic use of CBD, the purpose of the present study is to develop a Read More
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LC-MS/MS Determination of Bromperidol in Biological Matrices: Method Validation and Forensic Application
Authors: Marialinda Felli, Fabio De-Giorgio and Nadia De-GiovanniIn this paper, we describe a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method used to detect the antipsychotic drug bromperidol, in biological post-mortem fluids (urine, blood and vitreous humour). The method was used to investigate an unusual case of death which occurred after bromperidol ingestion. A 44 year-old woman arrived at the emergency department in cardiac arrest. Her sister rep Read More
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Development and Validation of a Rapid and Sensitive Assay for Simultaneous Quantification of Lenalidomide and Dexamethasone in Human Plasma by Liquid Chromatography Coupled to Tandem Mass-Spectrometry
Authors: Shanmugam Gopinath, Ramadass S. Kumar, Sekar Alexander and Palanisamy DanabalA high-performance liquid chromatographic assay with tandem mass spectrometric detection has been developed to simultaneously quantify lenalidomide (LEN) and dexamethasone (DEX) in human plasma to facilitate their combined clinical development. The analytes and the internal standard (IS) fluconazole were extracted from 250 μL aliquots of human plasma via liquid-liquid extraction in ethyl acetate. Chromatogr Read More
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A Validated Stability-Indicating LC Method for Simultaneous Determination of Enalapril and Hydrochlorothiazide in Pharmaceutical Samples
Authors: Marta De Diego, Sigrid Mennickent, Gloria Godoy and Valeska MirandaA stability-indicating liquid chromatographic method was developed and validated for the simultaneous determination of enalapril maleate and hydrochlorothiazide in drug substances and dosage forms. The method was developed using a RP-18 column with mobile phase containing methanol - tetrahydrofuran - phosphate buffer (pH 2.2; 0.01M) (32:5:63, v/v/v) at a flow rate of 1.0 mL min-1 and UV detection at 210 n Read More
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Enantioselective, Potentiometric Membrane Electrodes (EPME) Based on Maltodextrins for the Determination of L-Vesamicol in Serum Samples
Three EPMEs based on maltodextrins with different dextrose equivalent (DE) values [I (4.0-7.0), II (13.0-17.0) and III (16.5-19.5)], were designed for the determination of L-vesamicol. The linear concentration ranges of the proposed electrodes were 10-4 - 10-2 mol/L for maltodextrin I-based electrode, 10-5 -10-3 mol/L for maltodextrin II-based electrode and 10-9 - 10-7 mol/L for maltodextrin III-based electrode. The detection Read More
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Cyclodextrins Based Enantioselective, Potentiometric Membrane Electrodes (EPME) and their Applications for Enantioanalysis of L-Cysteine in Urine
Authors: Raluca-Ioana Stefan-van Staden, Luxolo Holo and Jacobus F. van StadenFour enantioselective, potentiometric membrane electrodes based on carbon paste impregnated with α-, β-, 2- hydroxyl-3-trimethylammoniopropyl -β- (as chloride salt) and γ-cyclodextrins are proposed for the enantioanalysis of Lcysteine. The proposed electrodes exhibited near-Nernstian slopes in a wide linear concentration range: 10-10 - 10-3 mol/L, with very low detection limits, near 10-11 mol/L. The surfaces of the elec Read More
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Simultaneous HPLC Determination of Metronidazole and Spiramycin in Plasma and Brain of Mouse
Authors: Chew W. Kit and Ignacio SegarraTreatments fail to eliminate Toxoplasma gondii due to low drug brain penetration. Spiramycin is an Mrp2, Pglycoprotein substrate, active in acute and chronic murine toxoplasmosis. Metronidazole is a CYP3A4 inhibitor and Pglycoprotein substrate. We developed a simple HPLC method to analyze spiramycin and metronidazole simultaneously. Male Balb/c mice were randomly selected in three groups and were dosed orally Read More
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A Simplified Approach to Calculating Kinetic Parameters of Thermal Decomposition Processes for Cephalosporin and Penicillin Sodium Salts and to Evaluating their Stabilities
Authors: Stefano Vecchio and Mauro TomassettiThe thermal stability and thermal decomposition behavior of sodium salts of some penicillins and cephalosporins have been studied using a differential scanning calorimetry technique under a stream of air with a linear heating rate up to 873 K. A “model-free” kinetic method based on the Kissinger equation was applied to decomposition processes of several penicillin and cephalosporin sodium salts to determine activati Read More
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A Fast and Simple Conductometric Method for Verapamil Hydrochloride Determination in Pharmaceutical Formulations
Authors: Fabio R. Caetano, Ava Gevaerd, Marcio F. Bergamini and Luiz H. MarcolinoA simple, precise, rapid, and low-cost conductometric method for verapamil hydrochloride determination in pharmaceutical formulations is described. Verapamil present in pharmaceuticals containing known quantities of the drug was conductometrically titrated in aqueous solution with silver nitrate using a conductometric cell coupled to an autotitrator. The method is based on the precipitation of chloride ions coming fro Read More
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Non-Transferrin Bound Iron - Determination in Biological Material and Clinical Implications
Authors: Artur Slomka, Katarzyna Piotrowska, Marcin Koba and Ewa ZekanowskaNon-transferrin bound iron (NTBI) is known to facilitate reactive oxygen species generation which contributes to the development of tissue damage observed in various disorders like hemolytic anemia, hemochromatosis, diabetes mellitus or many forms of neonatal central nervous system damage. Here we are summarizing information about biochemical nature of NTBI and review methods developed for its detection in bio Read More
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Mechanisms of Action of Imidazoacridinone and Triazoloacridinone Derivatives in View of their Biological Activity
Authors: Marcin Koba and Tomasz BaczekImidazoacridinones and triazoloacridinones are acridinone derivatives characterized by potent antitumor activity. From those, two of the most active compounds are C-1305 and C-1311. C-1305 was selected for extended preclinical trials, and C-1311 underwent phase II clinical trials for colon and breast cancers. These compounds exhibit biological (cytotoxic and/or antitumor) activity against various tumors including leuk Read More
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Volumes & issues
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Volume 20 (2024)
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Volume 19 (2023)
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Volume 18 (2022)
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Volume 17 (2021)
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Volume 16 (2020)
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Volume 15 (2019)
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Volume 14 (2018)
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Volume 13 (2017)
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Volume 12 (2016)
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Volume 11 (2015)
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Volume 10 (2014)
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Volume 9 (2013)
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Volume 8 (2012)
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Volume 7 (2011)
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Volume 6 (2010)
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Volume 5 (2009)
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Volume 4 (2008)
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Volume 3 (2007)
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Volume 2 (2006)
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Volume 1 (2005)
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