Current Pharmaceutical Analysis - Volume 7, Issue 1, 2011

5-fluorouracil (5-FU or f5U) is a pyrimidine analogue, and is used as an antineoplastic drug. Working with antineoplastic drugs constitutes a health hazard for the people who handle them, mainly because of their mutagenicity, teratogenicity and carcinogenicity. This is the reason, why the determination of antineoplastic drugs in wipe samples obtained from the hospital departments, where antineoplastic drugs are prepare Read More

Acarbose is a clinically useful drug for the treatment of type II insulin-independent diabetes as a hypoglycemic agent. This minireview summarized detection and separation methods for the analysis and determination of anti-diabetes drug acarbose and its structural analogs, including HPLC, enzyme-based biosensor and capillary electrophoresis. Besides the protocol, principle behind each technique is presented together with Read More

A reverse phase liquid chromatographic analytical method was developed for the simultaneous determination of Dapivirine and DS003 content in tablet dosage form. The chromatographic separation was achieved by using a C18 column with mobile phase containing a gradient mixture of 0.05% v/v trifluoroacetic acid in water as mobile phase A and acetonitrile as mobile phase B at a flow rate of 0.5 ml/min. Both of the ana Read More

Background: Although initially introduced for the management of hypertension, αl-adrenergic-receptor antagonists (αlblockers) have become the standard of care for the medical management of benign prostatic hyperplasia (BPH) related lower urinary tract symptoms (LUTS). Alpha-blockers (alfuzosin, tamsulosin, doxazosin, prazosin and terazosin) relax the smooth muscles in the prostate and are indicated for the symptomat Read More

It is the first systematic review to compare the bioanalytical methods to quantify the highly protein bound antimalarial, lumefantrine. We searched MEDLINE, SCIENCE DIRECT, GOOGLE and hand-searched journals and PhD theses. The inclusion criteria were, use of validated bioanalytical for quantification of lumefantrine in preclinical studies, healthy human volunteers and malaria patients. Ten bioanalytical methods were eligi Read More

Fast chiral liquid chromatographic methods are developed for the separation of bicalutamide and thalidomide enantiomers in bulk drug samples in an elution time of about 15 min. The chromatographic separation was carried out on various solvents using an amylose 3,5-dimethylphenylcarbamate immobilized onto silica gel (Chiralpak®-IA). The resolution (Rs) between the enantiomers is found to be great Read More

Counterfeiting is deeply rooted as it is being practiced since ancient times. It has been in this world for a long time, and is rapidly growing with the newly available growth in science and technology. The review provides an evidence of the growth and rising concerns of counterfeiting. Counterfeiting has been fuelled by corruption, inability to control, and also a rise in consumers who resort to such goods in the developin Read More

Drug formulations contain active pharmaceutical ingredients (APIs) and excipients. APIs present in the formulations contain some undesired impurity, which affects purity of the APIs. Therefore, with along % purity, impurity profiling is also needed to be carried out of all the APIs. Impurity profiling describes the account or description of maximum possible types of identified or unidentified impurities present in any APIs. The Read More