Current Pharmaceutical Analysis - Volume 5, Issue 3, 2009

The current interest in micro- and nano- scale devices has lead to their development for biomedical analysis. This ranges from static nucleic acid and protein arrays to complex analytical techniques based on chromatographic and electrokinetic techniques utilizing small-bore capillaries and chips. This review will describe the range of technologies available and examine the different platforms used in micro- and nano-device Read More

One of the main histopathological features of Alzheimer's disease (AD) is the formation of neuritic plaques in the brain of AD individuals. The aggregation of amyloid beta (Aβ) peptides is central to the formation of the plaques. In its native form, Aβ is unfolded but self-assembles into a β-sheet structure of ordered fibrils under various conditions. It was originally proposed that fibrillar Aβ deposits cause the various sympto Read More

A simple, rapid, reliable and fully validated square wave adsorptive stripping voltammetric procedure has been developed for the determination of rifampicin drug in bulk form, capsules and human urine in acetate buffer pH 5.0 which shows electrochemical reduction at a new Dysprosium nanowires modified carbon paste electrode (DyNW/CPE). In this paper, the modified carbon paste electrode (DyNW/CPE) exhibiting an el Read More

The atomic force microscope (AFM) is the subject of numerous papers and reports and is full of promises for nanoscience and nanotechnological applications. Pharmaceutical and biopharmaceutical studies using AFM have been functionalized during last two decades. Since, its invention in 1986, the number of published articles has considerably increased. Owing to its unique ability to not only image but also probe mechani Read More

In this work, water-compatible molecularly imprinted polymers (MIPs) were prepared for fast, accurate and selective solid-phase extraction of verapamil (VPM) from complex matrices such as biological fluids and human urine followed by its UV spectroscopic determination at 278 nm. The effective factors influencing the precipitation polymerization have been studied. Molecular recognition properties, binding capability and Read More

High performance liquid chromatography (HPLC), gas chromatography (GC), capillary electrophoresis (CE) and a number of immunoassay methods have been extensively applied to the analysis of antiepileptic drugs (AEDs) since many years ago providing reliable and accurate results. In addition, spectrophotometric and spectrofluorometric methods were developed for the analysis of AEDs. The available chemical methods for the Read More