Current Pharmaceutical Analysis - Volume 5, Issue 1, 2009

Identification and isolation of differentially expressed genes is of great interest for a broad range of medical and biological research fields. For pharmaceutical and pharmacological applications the identification of target genes is of importance as well as the investigation of the transcriptional response to drug administration. Over the last two decades several techniques have been developed for analyzing gene Read More

The majority of enantiomeric separations for purity analysis and quality control continue to be performed by normal phase liquid chromatography (LC) and supercritical fluid chromatography (SFC). For much of the pharmaceutical industry, chiral method development relies heavily on column screening activities. Much work has been performed looking at polysaccharide based stationary phases (Diacel AD, OD, AS, and OJ); how Read More

The electrochemical behaviors of N-(2-benzylbenzoxazol-5-yl)benzamide (B1), N-(2-benzylbenzoxazol-5-yl)- 4-nitrobenzamide (B2) and N-(2-(4-chlorobenzyl)benzoxazol-5-yl)-4-nitrobenzamide (B3) were investigated by cyclic voltammetry (CV), square wave voltammetry (SWV), differential puls voltammetry (DPV), chronoamperometry (CA) and bulk electrolysis (BE) techniques in dimethylsulfoxide (DMSO) containing 0.1 M te Read More

Tramadol, a 4-phenyl-piperidine analogue of codeine, is usually marketed as the hydrochloride salt and is a centrally acting analgesic, used for treating moderate to severe pain. In this study, a potentiometric liquid membrane sensors for simple and fast determination of tramadol hydrochloride in pharmaceutical formulation and urine was constructed. For the membrane preparation, tramadol-tetraphenyl borate c Read More

In the last months, 11 countries recalled heparin products because of severe side effects, which included 62 deaths reported to the FDA on or after January 1, 2008, in the USA. Active pharmaceutical ingredients have to fulfil quality requirements. The determination of the API's (Active Pharmaceutical Ingredients) quality relies on the results of analytical testing. The decisions, as to whether the quality is acceptable or no Read More

Chemical investigation of many bacterial and fungal, as well as plant species has revealed the presence of interesting compounds derived from naphthalene - 1,4-naphthoquinones and rarely also 1,2-naphthoquinones. They were detected in many species of families Bignoniaceae, Droseraceae, Plumbaginace, Boraginaceae, Juglandaceae as well as in species of small families, such as Dioncophyllaceae or Acanthace Read More

Drug analysis is important in several phases of drug development, such as formulation, stability studies and quality control. The importance of reliable analytical methods for drug determination in a fast, inexpensive, sensitive and selective way is thus evident. Although there are countless works describing new analytical methods for determination of drugs that act against tropical diseases, a review organizing these works i Read More