Current Pharmaceutical Analysis - Volume 16, Issue 2, 2020

Background: TJAB1099 is a novel, highly active inhibitor of human enterovirus 71 (HEV71), which is a most commonly found virus leading to Hand-Foot-Mouth Disease (HFMD). However, the TJAB1099 could not be detected in the plasma using a regular HPLC-UV detection during the pharmacokinetic study due to the poor solubility, which in turn limited the release prior to be absorbed by the gastrointestinal tract. Obj Read More

Purpose: A new multivariate chemometric approach was developed for fast and economic compatibility determinations of ranitidine hydrochloride (as model drug) with certain pharmaceutical; polymers (Alginate & Chitosan), excipient (Lactose) and intravenous fluids (Dextrose, Ringer & Dextrose/ Ringer). Binary mixtures of the drug and each item were prepared and investigated by chemometric- assisted UV- spectropho Read More

Introduction: A selective, sensitive, precise and rapid analytical method using liquid chromatography- tandem mass spectrometry (LC/MS/MS) for simultaneous determination of oseltamivir and oseltamivir carboxylic acid in plasma has been developed and validated, using oseltamivir-D5 and oseltamivir acid-D3 as internal standards. Methods: The analytes were extracted from 300μL of human plasma using solid phase extract Read More

Context: Benzoic acid is a kind of extensively used preservative. It is of great significance to detect benzoic acid by a rapid method for quality assurance and protection in the fields of pharmaceutical, food and chemistry industry. Objective: The present research is aimed to prepare polyaniline/Al bismuthate composite nanorods by an in-situ polymerizing process for effective detection of benzoic acid. Methods: The p Read More

Background: Menbutone is widely used as a veterinary choleretic drug in many countries. There was no publicly available analysis method for the determination of menbutone residues in swine tissues. It is necessary to establish a method to control the maximum residue limit and ensure food safety of the public. Objective: The aim of this study is to establish an analytical method for the simultaneous determination of menbuto Read More

Background: Cysteamine is used as an orphan drug in the treatment of cystinosis to prevent long-term cystine accumulation in lysosomes. Dosing in cysteamine treatment is extremely important and overdose may cause some side effects. Up to now, various analytical methods have been used for cysteamine determination. Many of these methods require sophisticated instruments, expert operators, time-consuming measurem Read More

Background: Hydrochlorothiazide (HCTZ) is a thiazide diuretic which comprises two sulfonamide groups. The literature is not clear regarding the identification of the chromatographic peaks of its two major related substances: chlorothiazide and 4-amino-6-chloro-1,3-benzenedisulfonamide (DSA). Methods: In the present study, a simple, sensitive, and selective HPLC method was developed and validated for the assay of HCT Read More

Background: In this work, a novel and extra sensitive blood sample determination method for on-line monitoring of Daptomycin is represented. Materials and Methods: This technique is in accordance with the electro-membrane extraction (EME) and stripping fast Fourier transform continuous cyclic voltammetry (SFFTCCV) coupling. Briefly, the potential waveform had become constantly utilized over a Gold Electrode Read More

Background: Smart different stability-indicating spectrophotometric methods have been established for the assay of chlordiazepoxide and clidinium bromide without the intervention of alkaline degradate of clidinium via various and different manipulating pathways without previous separation steps. Objective: The specificity of the established methods was inspected by analysing mixtures of cited drugs in the existence of the al Read More

Background: A Vortex-assisted dispersive liquid-liquid microextraction (VA-DLLME) method is presented for the determination of aspirin (acetylsalicylic acid) in human urine by spectrofluorimetry. Objective: To determine trace levels of aspirin in biologic samples by using green and low-cost method development. Methods: For the microextraction procedure, chloroform and acetonitrile were used as extraction and di Read More

Background: Erlotinib hydrochloride is a novel drug for the treatment of lung cancer. Objective: The objective of the present study was to design an uncomplicated and precise reverse phase high-performance liquid chromatography (RP-HPLC) method and optimize the chromatographic parameters using response surface methodology derived from Box Behnken design. The optimized method was validated for estimating Read More

Background: The rationality of cilnidipine tablets and capsules with four different pharmaceutical packaging materials was evaluated, and the structure of photodegradation impurities was analyzed by LC-Q-TOF. Materials and Methods: The impurity profiling of commercial cilnidipine tablets and capsules was analyzed by LC-Q-TOF for the further improvement of official monograph in pharmacopoeias and the source of the im Read More