Current Pharmaceutical Analysis - Volume 15, Issue 5, 2019

Introduction: Schizophrenia is seizures accompanied by severe psychotic symptoms, and a steady state of continuation in the form of periods of stagnation. Antipsychotics are now the basis of treatment for schizophrenia and there is no other molecule that is antipsychotic priority in treatment. Antipsychotics can be classified into two groups; dopamine receptor antagonists such as promazine, fluphenazine etc. and se Read More

Background: Cinnarizine, an antihistaminic drug, is commonly formulated in combination with domperidone and with paracetamol for treatment and prevention of motion sickness and migraine. Objective: The aim of this work was to develop new, simple, precise and selective chromatographic methods (RP-HPLC and TLC-densitometric methods) for the determination of these drugs. These methods can be used Read More

Introduction: This study aimed at developing a technology to measure the hardness of Ibuprofen (IBU) tablets and optimize the IBU formulation using Near-infrared (NIR) spectroscopy. Materials and Methods: Tablets (400 mg±5%, 10mm in diameter) consisting of IBU, microcrystalline cellulose SH-103, carboxymethyl starch sodium, magnesium stearate, silicon dioxide were formed of various hardness (2kg, 4kg, 6kg, 8 Read More

Introduction: A sensitive analytical method based on functionalized multi walled carbon nanotubes reinforced hollow fiber solid/liquid phase microextraction (F-MWCNTs-HF-SLPME) forwarded with HPLC-DAD for analyzing phenazopyridine from urine is presented. Materials and Methods: The extraction of phenazopyridine is performed using specially designed FMWCNTs- HF-SLPME device constructed as follows: the functio Read More

Background: The quality control indexes detected by the existing methods are less and lack specificity, and cannot truly reflect their intrinsic quality because of the similarity of Schisandra chinensis and Schisandra sphenanthera in both their appearance and their main chemical composition. Therefore, it is urgent to establish an effective method for the quality control of the both. High-performance capillary electrophoresis (H Read More

Background: Erding granule (EDG) widely used as an agent with the effect of heat-clearing, detoxifying, eliminating dampness, relieving jaundice and upper respiratory tract disease in clinical application, but the systematic chemical information and anti-hyperuricemia effect of EDG was still unclear. Methods: An ultra-high performance liquid chromatography combined with electrospray ionization quadrupole time-of-flight ma Read More

Background: Aminoglycosides are non-chromophoric antibiotics. The official method of assay in pharmacopoeias is microbiological. Bioassay methods are potency-semi-quantitative, laborious and time-consuming. In contrast, spectrophotometric methods are rapid, convenient, specific, sensitive and selective. The presence of NH2 and -OH functional groups in aminoglycosides makes them susceptible to redox reaction. O Read More

Background: Magnoliae Officinalis Cortex is a well-known traditional Chinese herbal medicine with vast clinical consumption owing to its positive effects. However, little attention has been devoted to analyzing the dynamic changes of the chemical constituents of Magnoliae Officinalis Cortex in different growth periods. Methods: In this study, all analyses were performed on UFLC -20ADXR system and a SynergiTM Hydro-RP 100 Read More

Introduction: A rapid, and accurate Ultra Performance Liquid Chromatography (UPLC) method was developed to simultaneously analyze Methocarbamol, Paracetamol and the related substances. Materials and Methods: Waters ACQUITY UPLC® BEH Phenyl C18 column was used in conjunction with UV detection at 225nm. Gradient elution with 0.05M, pH 6 phosphate buffer and acetonitrile flow at 0.3mL /min rate we Read More

Background: Amikacin sulfate (AMK) belongs to the class of aminoglycoside antibiotics. It is effective against the infections caused by Gram-negative and positive bacteria. AMK lacks a chromophore group in its structure and, therefore, it does not absorb light in the 200-800 nm region which makes it a difficult molecule to analyze by UV detector using high performance liquid chromatography (HPLC). Objective: This stud Read More

Background: Topiramate (TPM), an anticonvulsant drug, was determined in human serum and in umbilical cord blood. TPM can produce severe damage to the fetus (baby into mother´s uterus), and it is not always possible that epileptic women change their drug during pregnancy, because some antiepileptic drugs are not effective on some people. Using pregnant-mother serum blood, we can estimate drug levels in fetus se Read More

Background: Monitoring of DA, in the presence of other chemical analogues such as epinephrine, norepinephrine, serotonin, ascorbic acid, uric acid, catechol, phenethylamine, tyramine, and tyrosine, is crucial in the diagnosis and mechanistic understanding of human neuropathology. Therefore, the determination of DA at trace levels has become a very important analytical task, as part of health safety and forensic an Read More

Background: Developing a simple analysis method for quantification of drug concentration is one of the essential issues in pharmacokinetic and therapeutic drug monitoring studies. Objective: A fast and reliable dispersive liquid-liquid microextraction procedure was employed for preconcentration of verapamil in exhaled breath condensate (EBC) samples and this was followed by the determination with high-perfor Read More

Background: Xanthium sibiricum is a well-known traditional Chinese medicine (TCM) that has been commonly used to treat rhinitis and related nasal diseases. The aim of this study was to develop a comprehensive analytical method based on high-performance liquid chromatographyelectrospray ionization coupled with triple quadrupole-linear ion trap mass spectrometry (LC-ESIQTRAP- MS/MS) for the simultaneous determination o Read More

Introduction: Macitentan is an endothelin receptor antagonist drug used in the treatment of pulmonary arterial hypertension. Materials and Methods: A new, sensitive, simple, accurate and rapid ultra-performance liquid chromatography in combination with tandem triple quadruple mass spectrometry (UPLC-MS/MS) method has been developed and validated for the determination of macitentan in pharmaceutical formulati Read More