Current Pharmaceutical Analysis - Volume 15, Issue 3, 2019

Background: Electrochemical techniques can easily be adopted to solve many problems of pharmaceutical interest. The implementation of electroanalytical methods in the assay of pharmaceutical formulations has increased greatly. Nowadays, owing to the critical importance of electron transfer and surface properties, chemically modified electrodes have been employed in electrochemical sensors. The chemicall Read More

Background: Drug stability is essential in the process of drug production, storage, appliance, and so on. Some drugs' degradation products may even have a toxic side effect, which can result in safety risks and economic losses. Therefore, it is very imperative to develop a suitable stability indicating an analytical method for anastrozole which could be used for stability testing, routine and in-process quality control analysis o Read More

Introduction: Artificial enzyme mimics are materials with similar catalytic function of natural enzymes. Among several types of artificial enzymes, nanomaterial-based products or nanozymes have been of particular interest to researchers. Materials and Methods: In this work, Ce2(MoO4)3 nanoplates were synthesized via a one-pot hydrothermal approach. SEM and EDS characterizations show a plated-like architecture with Read More

Background: It is urgently needed to clarify the pharmacokinetic mechanism for the multibioactive constituents in Traditional Chinese Medicines for its clinical applications. A rapid, sensitive and reliable ultra-performance liquid chromatography-tandem mass spectrometry method was developed and validated for the simultaneous determination of Danshensu, Ferulic acid, Astragaloside IV, Naringin, Neohesperidin and Puerarin aft Read More

Introduction: Trimetazidine and Metoprolol combination is more effective in the treatment of cardiac disorders as compared to single drug therapy. Materials and Methods: A rapid, simple, and sensitive HPTLC method was developed for the simultaneous determination of Trimetazidine and metoprolol from its tablet dosage form and validated. In HPTLC method, standard and sample solutions of Trimetazidine hydrochloride a Read More

Background: Molecularly imprinted polymers (MIPs) are synthetic polymers that have a selective site for a given analyte, or a group of structurally related compounds, that make them ideal polymers to be used in separation processes. Objective: An optimized molecularly imprinted polymer was selected and applied for selective extraction and analysis of clozapine in rat brain tissue. Methods: A molecularly imprinted solid-phase e Read More

Background: A robust and validated analytical method is a key component at various stages of pharmaceutical product development to ensure identity, purity and quality of drugs and formulations. Objective: The aim of proposed work was to develop and validate a simple, sensitive and stability indicating high performance liquid chromatographic method for the estimation of venlafaxine hydrochloride in bulk and formula Read More

Background: Salvianolic acid A (SAA) is a polyphenolic acid extracted from Salvia miltiorrhiza Bunge. It showed protective effect against diabetic complications after oral administration with a low bioavailability of 1.42%. Attempts have been made to develop it into a new medication. Intracorporal process of SAA is indistinct and no report regarding the excretion is available. Our preliminary experiment revealed that pr Read More

Background: The unstable and/or toxic degradation products may form due to degradation of drug which results into loss of therapeutic activity and lead to life threatening condition. Hence, it is important to establish the stability characteristics of drug in various conditions such as in temperature, light, oxidising agent and susceptibility across a wide range of pH values. Introduction: The aim of the proposed study was Read More

Background: The presence of impurities in vancomycin compromised the safety and contributed to decrease of its use for years. In Brazil, vancomycin generic drug represents an option to reduce hospital costs. However, the controversy over the quality of these formulations and their relationship to effectiveness and safety raised concerns. Objective and Methods: To assess in vitro quality of vancomycin injections throu Read More

Background: Alpiniae Oxyphyllae Fructus (Yizhi in Chinese) have been widely used as an herbal medicine for the treatment of diuresis, enuresis and diarrhea in China. Many studies have deciphered some potential underlying mechanisms for its anti-diarrheal effects. However, tissue distribution of Yizhi constituents is warranted because pharmacological receptors are frequently located in tissues. Moreover, it is also interesting to kn Read More