Current Proteomics - Online First

Background Centella asiatica is a tropical medicinal herb traditionally used for the treatment of different diseases, such as arthritis, kidney disease, diabetes mellitus, etc. Diabetes mellitus is emerging as a global health concern, demanding research to provide insights into it. Objective The current research study aimed at employing the Network Pharmacology and Molecular Docking approach to unearth and validate the po Read More

Background Post-Translational Modifications (PTMs) are covalent modifications of amino acids added to proteins that can significantly affect proteins’ structures and functions. PTMS are, therefore, important biomarkers due to their regulation of various bioactivities. Protein array is a robust tool for detecting and quantifying proteins with high throughput, small sample requirement, and high sensitivity. Objectives On th Read More

Background Bovine Seminal Ribonuclease (BS-RNase) is a unique member of the RNase A family found in the bovine seminal fluid. It is recognized for its antiviral and antitumor properties, which make it a potential therapeutic agent. Objective This study aimed to compare the stability of monomeric and dimeric forms of BS-RNase using in silico methods. Method The tertiary structures of BS-RNase as monomers and dime Read More

Introduction Acinetobacter baumannii is a well-known, multidrug-resistant bacteria that poses a serious risk to public health everywhere. The discovery of novel antibacterial drugs has become an urgent need due to the emergence of multi-drug resistance strains and the lack of appropriate antibiotics. To develop effective treatments for A. baumannii infections, this work explores the evolutionary analysis of Outer Read More

Background Hantavirus illness is characterized by increased vascular permeability and hemorrhagic fever with renal syndrome or cardiopulmonary syndrome. Methods In this study, the domain search approach, a bioinformatics method, was utilized to understand more about hantavirus E protein structures. Results Activities of Ca2+ binding domain, C-type lectin, Dockerin, glycosyl hydrolase (cellulase), PI3K, threonine kina Read More

Background Entrapment is supposed to be the most effective and simple method among various strategies of enzyme immobilization as it preserves the original conformation and biological activity of the enzyme with greater immobilization yield. A suitable and cost-effective protocol for the entrapment of 1,4-α-D-glucan glucanohydrolase obtained from halotolerant Micrococcus spp., K11 has been developed. Objectiv Read More

Background Curcumin possesses numerous properties, including anti-influenza effects. Various natural analogs and metabolites of curcumin have been identified. Objective To better understand the mechanism of curcumin's anti-influenza effect, the inhibitory effect of natural analogs and secondary metabolites of curcumin on 11 influenza virus proteins was investigated in a simulated environment. Methods Molecular data Read More

Introduction Polyamines are vital in regulating stress signaling pathways, inhibiting reactive oxygen species, and stabilizing the photosynthetic apparatus in plants, with their levels fluctuating under stress conditions. Among the key enzymes in polyamine biosynthesis is spermidine synthase, which synthesizes spermidine in the presence of putrescine and S-adenosyl 3-(methylsulfanyl) propylamine. Methods This study focused Read More

Objective This pilot study aimed to analyze serum differential proteins in Vestibular Migraine (VM) group (n=21) and the healthy controls (HC) group (n=21). Methods Serum samples collected from subjects were analyzed using the relative quantitative proteomics Tandem Mass Tag (TMT) quantification technique for protein identification. Results Based on TMT proteomics technology and bioinformatics analysis, we identifie Read More

Background The identification and classification of natural products are vital in drug discovery and bioactive compound exploration. Traditional methods are laborious and time-consuming, necessitating innovative tools for accurate predictions using advanced AI techniques. Objectives This paper presents NaturePred, a user-friendly tool designed to predict the class of natural products and calculate eight physicochemical pr Read More

The incidence of Hepatocellular carcinoma (HCC) is rising at an alarming rate. It is now the third leading cause of cancer deaths worldwide. Non-alcoholic fatty liver disease (NAFLD) and its more aggressive form of non-alcoholic steatohepatitis (NASH) are emerging as significant risk factors for liver cirrhosis and HCC. Post-translational modifications in proteins especially glycosylation leading to the synthesis of glycoproteins h Read More

Aim Among the most prevalent subtypes of acute leukemia is acute myeloid leukemia (LAML). Consequently, it is essential to understand the molecular causes of LAML and find its predictive and diagnostic biomarkers. The aim of this study is to determine the molecular functions of fibroblast growth factor receptor 1(FGFR1) involved in LAML pathogenesis and its potential therapeutic effect for AML treatment. Metho Read More

Introduction Proteins present in body fluids harbor the potential to act as markers for both diagnosing diseases and exploring their underlying mechanisms. As urine can be easily obtained non-invasively, analyzing its proteins is an ideal approach to identifying biomarkers for bladder cancer. This study aimed to identify proteins in urine that could serve as biomarkers for bladder cancer. Method Urine samples were collected fr Read More