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image of The Severity of Disease and Hospital Length of Stay for the First and Second Admission of COVID-19 Patients: An Observational Study from Southeastern Iran

Abstract

Background

This study aimed to investigate the severity of disease and length of hospital stay for COVID-19 patients admitted to a hospital in southeastern Iran.

Method

This cross-sectional study was conducted in Kerman, Iran. Data were collected from patients who visited Afzalipour Hospital in Kerman more than twice during the COVID-19 epidemic from the end of February 2020 to March 21, 2021. We conducted two key analyses: 1. Mixed effect logistic regression was used to check the relationship between the variables and COVID-19 severity. 2. Mixed effect linear regression was used to check the relationship between the variables and the length of stay in the hospital.

Results

The findings indicated that the most important risk factors for the severity of COVID-19 were heart diseases (OR=1.67,95%CI:1.20-2.30), increasing age (OR=2.23 for age>54, 95%CI:1.70-2.90), male gender (OR=1.47,95%CI:1.10-1.96), respiratory diseases other than asthma, and frequency of admission (OR=1.60,95%CI:1.20-2.15). All patients who underwent readmission experienced a shorter duration of hospitalization during their subsequent admission (OR=0.94,95%CI:0.91,0.96) and had a higher mortality rate (30% within 14 days, 26.6% between 14-90 days). Patients readmitted at intervals of 14-90 days and greater than 90 days exhibited lower disease severity compared to those readmitted within the 0-14 day period.

Conclusion

Examining readmissions, the severity of COVID-19, and the length of hospital stay in affected patients are important factors for planning and allocating resources for COVID-19 management and treatment. These factors can help policymakers develop effective clinical guidelines for hospitalization or outpatient treatment of COVID-19 patients and contribute to reducing the burden of disease in the community.

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/content/journals/covid/10.2174/0126667975341163241129050027
2024-12-13
2025-01-19
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References

  1. WHO COVID-19 dashboard. 2024 Available from: https://data.who.int/dashboards/covid19/cases?n=c
  2. Ahmadi Gohari M. Chegeni M. Haghdoost A.A. Mirzaee F. White L. Kostoulas P. Mirzazadeh A. Karamouzian M. Jahani Y. Sharifi H. Excess deaths during the COVID-19 pandemic in Iran. Infect. Dis. (Lond.) 2022 54 12 909 917 10.1080/23744235.2022.2122554 36121798
    [Google Scholar]
  3. Nakhaeizadeh M. Chegeni M. Adhami M. Sharifi H. Gohari M.A. Iranpour A. Azizian M. Mashinchi M. Baneshi M.R. Karamouzian M. Haghdoost A.A. Jahani Y. Estimating the number of COVID-19 cases and impact of new COVID-19 variants and vaccination on the population in Kerman, Iran: A mathematical modeling study. Comput. Math. Methods Med. 2022 2022 1 11 10.1155/2022/6624471 35495892
    [Google Scholar]
  4. Zhu H. Wei L. Niu P. The novel coronavirus outbreak in Wuhan, China. Glob. Health Res. Policy 2020 5 1 6 10.1186/s41256‑020‑00135‑6 32226823
    [Google Scholar]
  5. Loo W.K. Hasikin K. Suhaimi A. Yee P.L. Teo K. Xia K. Qian P. Jiang Y. Zhang Y. Dhanalakshmi S. Azizan M.M. Lai K.W. Systematic review on COVID-19 readmission and risk factors: Future of machine learning in COVID-19 readmission studies. Front. Public Health 2022 10 898254 10.3389/fpubh.2022.898254 35677770
    [Google Scholar]
  6. Weaver F.M. Niederhausen M. Hickok A. O’Neill A.C. Gordon H.S. Edwards S.T. Govier D.J. Chen J.I. Young R. Whooley M. Hynes D.M. Hospital readmissions among veterans within 90 days of discharge following initial hospitalization for COVID-19. Prev. Chronic Dis. 2022 19 220200 10.5888/pcd19.220200 36455563
    [Google Scholar]
  7. Alinejad H. Vazirinejad R. Sayadi A. Hajaliakbari Z. Pakzad Moghadam S.H. Ahmadi M. Alinejad M. Dehghan Menshadi Z.S. The relationship between COVID-19-induced death and chronic diseases. J. Client-Centered Nurs. Care 2021 7 3 167 174 10.32598/JCCNC.7.3.334.3
    [Google Scholar]
  8. Nematshahi M. Soroosh D. Neamatshahi M. Attarian F. Rahimi F. Factors predicting readmission in patients with COVID-19. BMC Res. Notes 2021 14 1 374 10.1186/s13104‑021‑05782‑7 34565442
    [Google Scholar]
  9. Kuehn B.M. Hospital readmission is common among COVID-19 survivors. JAMA 2020 324 24 247 10.1001/jama.2020.23910
    [Google Scholar]
  10. Donnelly J.P. Wang X.Q. Iwashyna T.J. Prescott H.C. Readmission and death after initial hospital discharge among patients with COVID-19 in a large multihospital system. JAMA 2021 325 3 304 306 10.1001/jama.2020.21465 33315057
    [Google Scholar]
  11. McCarthy C.P. Murphy S. Jones-O’Connor M. Olshan D.S. Khambhati J.R. Rehman S. Cadigan J.B. Cui J. Meyerowitz E.A. Philippides G. Friedman L.S. Kadar A.Y. Hibbert K. Natarajan P. Massaro A.F. Bohula E.A. Morrow D.A. Woolley A.E. Januzzi J.L. Wasfy J.H. Early clinical and sociodemographic experience with patients hospitalized with COVID-19 at a large American healthcare system. EClinicalMedicine 2020 26 100504 10.1016/j.eclinm.2020.100504 32838244
    [Google Scholar]
  12. Pouredalati M. Sharifpoor E. Dastyar N. Hosseinnataj A. Khajoie F. Ahmadi A. Shafiei-Bafti M. Influential factors related to patient hospitalization due to COVID-19: A cross-sectional study. Coronaviruses 2024 5 10.2174/0126667975285430240123092043
    [Google Scholar]
  13. Buskermolen M. te Paske K. van Beek J. Kortbeek T. Götz H. Fanoy E. Feenstra S. Richardus J.H. Vollaard A. Relapse in the first 8 weeks after onset of COVID-19 disease in outpatients: Viral reactivation or inflammatory rebound? J. Infect. 2021 83 2 e6 e8 10.1016/j.jinf.2021.06.015 34147529
    [Google Scholar]
  14. Gohari M.A. Haghdoost A.A. Ahmadinejad M. The impact of COVID-19 on trauma emergency patients in Southeastern Iran. Bull. Emerg. Trauma 2024 2 2 15 24 [BEAT]. 10.30476/BEAT.2024.101960.1500
    [Google Scholar]
  15. Lavery A.M. Preston L.E. Ko J.Y. Chevinsky J.R. DeSisto C.L. Pennington A.F. Kompaniyets L. Datta S.D. Click E.S. Golden T. Goodman A.B. Mac Kenzie W.R. Boehmer T.K. Gundlapalli A.V. Characteristics of hospitalized COVID-19 patients discharged and experiencing same-hospital readmission - United States, March-August 2020. MMWR Morb. Mortal. Wkly. Rep. 2020 69 45 1695 1699 10.15585/mmwr.mm6945e2 33180754
    [Google Scholar]
  16. Atalla E. Kalligeros M. Giampaolo G. Mylona E.K. Shehadeh F. Mylonakis E. Readmissions among patients with COVID‐19. Int. J. Clin. Pract. 2021 75 3 e13700 10.1111/ijcp.13700 32894801
    [Google Scholar]
  17. Chen M. An W. Xia F. Yang P. Li K. Zhou Q. Fang S. Liao Y. Xu X. Liu J. Liu S. Qin T. Zhang J. Wei W. Zhang Y. Zhang G. Zhang M. Clinical characteristics of rehospitalized patients with COVID‐19 in China. J. Med. Virol. 2020 92 10 2146 2151 10.1002/jmv.26002 32401361
    [Google Scholar]
  18. Uyaroğlu O.A. Başaran N.Ç. Özişik L. Di̇zman G.T. Eroğlu İ. Şahi̇n T.K. Taş Z. İnkaya A.Ç. Tanriöver M.D. Metan G. Güven G.S. Ünal S. Thirty-day readmission rate of COVID-19 patients discharged from a tertiary care university hospital in Turkey: An observational, single-center study. Int. J. Qual. Health Care 2021 33 1 mzaa144 10.1093/intqhc/mzaa144 33104780
    [Google Scholar]
  19. Finn A. Tanzer J.R. Jindal A. Selvaraj V. Collins B. Dapaah-Afriyie K. Readmission risk after COVID-19 hospitalization: A moderation analysis by vital signs. South. Med. J. 2022 115 11 842 848 10.14423/SMJ.0000000000001472 36318952
    [Google Scholar]
  20. Nguyen N.N. Houhamdi L. Hoang V.T. Delerce J. Delorme L. Colson P. Brouqui P. Fournier P.E. Raoult D. Gautret P. SARS-CoV-2 reinfection and COVID-19 severity. Emerg. Microbes Infect. 2022 11 1 894 901 10.1080/22221751.2022.2052358 35264078
    [Google Scholar]
  21. Medić S. Anastassopoulou C. Lozanov-Crvenković Z. Vuković V. Dragnić N. Petrović V. Ristić M. Pustahija T. Gojković Z. Tsakris A. Ioannidis J.P.A. Risk and severity of SARS-CoV-2 reinfections during 2020–2022 in Vojvodina, Serbia: A population-level observational study. Lancet Reg. Health Eur. 2022 20 100453 10.1016/j.lanepe.2022.100453 35791336
    [Google Scholar]
  22. Deng J. Ma Y. Liu Q. Du M. Liu M. Liu J. Severity and outcomes of SARS-CoV-2 reinfection compared with primary infection: A systematic review and meta-analysis. Int. J. Environ. Res. Public Health 2023 20 4 3335 10.3390/ijerph20043335 36834029
    [Google Scholar]
  23. Somani S.S. Richter F. Fuster V. De Freitas J.K. Naik N. Sigel K. Bottinger E.P. Levin M.A. Fayad Z. Just A.C. Charney A.W. Zhao S. Glicksberg B.S. Lala A. Nadkarni G.N. Characterization of patients who return to hospital following discharge from hospitalization for COVID-19. J. Gen. Intern. Med. 2020 35 10 2838 2844 10.1007/s11606‑020‑06120‑6 32815060
    [Google Scholar]
  24. Li X. Zhong X. Wang Y. Zeng X. Luo T. Liu Q. Clinical determinants of the severity of COVID-19: A systematic review and meta-analysis. PLoS One 2021 16 5 e0250602 10.1371/journal.pone.0250602 33939733
    [Google Scholar]
  25. Ahmadi Gohari M. Chegeni M. Mehrolhassani M.H. Haghdoost A.A. Mirzaee M. Comparing the emergency care of Iranian and Afghan patients during the COVID-19 pandemic. Arch. Iran Med. 2024 27 3 142 150 10.34172/aim.2024.22 38685839
    [Google Scholar]
  26. Mohtashami A. Ahmadi Gohari M. Bahrampour A. Mehrolhassani M.H. Jahani Y. Risk factors associated with mortality in hospitalized COVID-19 patients: A case study from Southeast Iran. J. Kerman Univ. Med. Sci. 2024 31 2 72 78 10.34172/jkmu.2024.13
    [Google Scholar]
  27. Mauvais-Jarvis F. Aging, male sex, obesity, and metabolic inflammation create the perfect storm for COVID-19. Diabetes 2020 69 9 1857 1863 10.2337/dbi19‑0023 32669390
    [Google Scholar]
  28. Raimondi F. Novelli L. Ghirardi A. Russo F.M. Pellegrini D. Biza R. Trapasso R. Giuliani L. Anelli M. Amoroso M. Allegri C. Imeri G. Sanfilippo C. Comandini S. Hila E. Manesso L. Gandini L. Mandelli P. Monti M. Gori M. Senni M. Lorini F.L. Rizzi M. Barbui T. Paris L. Rambaldi A. Cosentini R. Guagliumi G. Cesa S. Colledan M. Sessa M. Masciulli A. Gavazzi A. Buoro S. Remuzzi G. Ruggenenti P. Callegaro A. Gianatti A. Farina C. Bellasi A. Sironi S. Fagiuoli S. Di Marco F. Covid-19 and gender: Lower rate but same mortality of severe disease in women - An observational study. BMC Pulm. Med. 2021 21 1 96 10.1186/s12890‑021‑01455‑0 33743654
    [Google Scholar]
  29. Akbari A. Fathabadi A. Razmi M. Zarifian A. Amiri M. Ghodsi A. Vafadar Moradi E. Characteristics, risk factors, and outcomes associated with readmission in COVID-19 patients: A systematic review and meta-analysis. Am. J. Emerg. Med. 2022 52 166 173 10.1016/j.ajem.2021.12.012 34923196
    [Google Scholar]
  30. Zaboli R. Mousavi S.M. Bahadori M. Mehdizadeh P. Asgharzadeh A. Delavari A. Influential factors on the hospitalization length of COVID-19 patients: A systematic review. Trauma Mon. 2022 27 Especial Issue (COVID-19 and Emergency Medicine) 82 99 10.30491/tm.2022.312499.1395
    [Google Scholar]
  31. Vijayalakshmi K.P. Srikanth A.K. Mudhol R.R. Mohite V. Ravindra J.G. Sadanand S. Srinidhi Y. Predictors of duration of hospital stay in COVID-19 disease: A retrospective study. J. Clin. Diagn. Res. 2022 16 10 10.7860/JCDR/2022/57264.16853
    [Google Scholar]
/content/journals/covid/10.2174/0126667975341163241129050027
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  • Article Type:
    Research Article
Keywords: Iran ; COVID-19 ; hospital length of stay (LOH) ; patient admission
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