Synthesis and Biological Activity of 2,6-Naphthyridine Derivatives: A Mini Review

The broad spectrum of biological activity of 2,6-naphthyridine, one of the six structural isomers of pyridopyridine, is the main reason for the development of new compounds containing this scaffold. This review paper aims to present various methods for obtaining 2,6-naphthyridine analogues and their biological activity, which have been reported in the scientific literature. Compounds containing the 2,6-naphthyridine moiety can be isolated from plants or obtained synthetically from various substrates: pyridine derivatives, other heterocyclic derivatives, or acyclic compounds. Biological investigations have shown that these compounds exhibit various biological activity; among others, they have an effect on the central nervous system or anticancer or antimicrobial activity.