An Overview of Recent Advances in Isatin-Based Multicomponent Reactions

Isatin has been widely deployed in multicomponent reactions to prepare diverse heterocyclic compounds, which have garnered the attention of organic chemists considering their anti-inflammatory, anti-microbial, and antiviral activities, among others. This review discusses the applications of isatin in multicomponent reactions from 2019 to 2022. Isatin has been used as a raw material in multicomponent reactions due to its diverse biological and therapeutic activities. This overview may help stimulate the readers to exploit such convergent strategies in their synthetic endeavors.