Resorcin[4]arenes: Generalities and Their Role in the Modification and Detection of Amino Acids

The characteristics and properties that enable resorcin[4]arenes to self-assemble in order to form derivatives with amino acids with a high potential for application in various fields are reviewed. In particular, resorcin[4]arene synthesis, their characteristics, the variety in the size of cavity, their functional groups, and their applications associated with molecular interactions are described in this study. Also, the types of amino acids that can be recognized by resorcin[4]arenes, their interactions, the techniques that allow the determination of the association constants, and the evaluation of the stoichiometry of the complex formed, are reviewed.