- ISSN: 1385-2728
- E-ISSN: 1875-5348
-
s Synthesis and In Vitro Antitumor Effect of New Vindoline-steroid Hybrids
- Source: Current Organic Chemistry, Volume 23, Issue 8, Apr 2019, p. 959 - 967
-
- 01 Apr 2019
Abstract
10-Aminovindoline and 17-desacetylvindoline were coupled with 5α- dihydrotestosterone hemisuccinate and 19-nortestosterone hemisuccinate. As a result, four vindoline-steroid hybrids were synthesized via a succinate linker. One of the new hybrid compounds showed significant anticancer effect in vitro in the case of colon cancer and melanoma cell lines.
© Bentham Science Publishers
