Synthesis of (2-iminomethyl)pyridine Moiety Supported on Hydroxyapatite-encapsulated-γ-Fe2O3 as an Inorganic-organic Hybrid Magnetic Nanocatalyst for the Synthesis of Thiazole Derivatives under Ultrasonic Irradiation

A novel pyridine base modified core-shell (γ-Fe2O3@Hap (Hap: Hydroxyapatite)) inorganic-organic hybrid magnetic nanocatalyst has been introduced. The catalyst was fully characterized by spectroscopic analyses (FT-IR, FESEM, EDX, XRD) and its efficiency evaluated as a basic catalyst in one-pot multicomponent reaction of aryl aldehydes, rhodanine and piperidine under ultrasonic irradiation to obtain thiazole derivatives. This green, fast and straightforward protocol produced the products in short reaction times (14-40 min) and high to excellent yields (75-95%).