Applications of Tandem Diels-Alder/Sigmatropic Rearrangement Reactions to Natural Product Synthesis

In this non-comprehensive review a selection of tandem processes combining sigmatropic rearrangement with Diels-Alder reactions is presented. The synthetic utility of these two transformations is indisputable as they can lead to complex natural products in an efficient and selective way. Most of the examples presented here have been chosen in view of their application to natural products synthesis. The emphasis of the discussion is put on the illustration of new strategic disconnections becoming accessible thanks to tandem processes.