Organic Chemistry Tool for Nanoparticles Monofunctionalization and Their Biomedical Applications

In the past few decades, there has been great interest in the monofunctionalization of inorganic nanoparticles using organic chemistry tool. However, the uncontrollability in the degree of nanoparticle functionalization and the number of functional groups on the nanoparticles restrict their applications. It is now realized that precisely controlling the composition of the nanoparticles (NPs) will be of great importance for many biomedical applications. In this review, we will focus on using organic chemistry tools for monofunctionalization of inorganic nanoparticles, biomedical applications of monofunctionalized NPs, and then also discuss recent advances and future prospects in this emerging field.