Some Recent Synthetic Development on Compounds with Potent Activities on Hormone-sensitive Breast Cancers

Hormone-sensitive breast cancers correspond to breast tumors with the existence of estrogen and progesterone in the tumor issue. The hormones estrogen and progesterone may in some circumstance promote the growth of breast cancers. Therefore, compounds targeting hormone-sensitive breast cancers have attracted considerable interest from synthetic organic chemists. In the past two decades, numerous compounds have thus been designed and synthesized to investigate their anti-breast cancer activities. In this review, some recent synthetic endeavor in the past five years towards compounds targeting hormone-sensitive breast cancers, especially estrogenreceptor positive breast cancers, are summarized.