Strategies and Methods for the Synthesis of Anticancer Natural Product Neopeltolide and its Analogs

Neopeltolide, isolated in 2007, with its novel structural features and potent anti-cancer cell proliferation activity, has attracted a tremendous amount of synthetic efforts. This review briefly and chronologically summarizes each synthesis with the main focus on the strategies and methodologies for the construction of its cistetrahydropyran- containing macrolactone core.