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- ISSN: 1385-2728
- E-ISSN: 1875-5348
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Cancer-Fighting Molecules-Taxol and its Analogs
- Source: Current Organic Chemistry, Volume 16, Issue 17, Sep 2012, p. 2038 - 2052
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- 01 Sep 2012
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Abstract
Natural products have not only yielded new and effective drugs but have also provided insight into new mechanisms of action. Paclitaxel (Taxol) as the first promoters of tubulin polymerization plays important roles in the war against cancer and in the exploring new microtubule-binding drugs. The present review summarized the development of paclitaxel and its analogues which can be used as the precurce of synthesis of Taxol and its analogues.
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