Facile Synthesis of Imidazolidines by Condensation of Aromatic Amines with Glyoxal and Formaldehyde

Jian-Qi Zhu; Jia Li; Xin Wang; Ping Fan; Xiao-Nan Wang; Li-Jing Bian; Hao-Qiu Li; Yun-Qi Tian

doi:10.2174/138527212800840874

ISSN: 1385-2728
E-ISSN: 1875-5348

Facile Synthesis of Imidazolidines by Condensation of Aromatic Amines with Glyoxal and Formaldehyde
Authors: Jian-Qi Zhu¹, Jia Li², Xin Wang³, Ping Fan⁴, Xiao-Nan Wang⁵, Li-Jing Bian⁶, Hao-Qiu Li⁷ and Yun-Qi Tian⁸
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¹ Institute of Chemistry for Functionalized Materials, College of Chemistry and Chemical Engineering, Liaoning Normal University, Huang-He Road 850, Dalian, 116029, R.P. China. ² Institute of Chemistry for Functionalized Materials, College of Chemistry and Chemical Engineering, Liaoning Normal University, Huang-He Road 850, Dalian, 116029, R.P. China. ³ Institute of Chemistry for Functionalized Materials, College of Chemistry and Chemical Engineering, Liaoning Normal University, Huang-He Road 850, Dalian, 116029, R.P. China. ⁴ Institute of Chemistry for Functionalized Materials, College of Chemistry and Chemical Engineering, Liaoning Normal University, Huang-He Road 850, Dalian, 116029, R.P. China. ⁵ Institute of Chemistry for Functionalized Materials, College of Chemistry and Chemical Engineering, Liaoning Normal University, Huang-He Road 850, Dalian, 116029, R.P. China. ⁶ Institute of Chemistry for Functionalized Materials, College of Chemistry and Chemical Engineering, Liaoning Normal University, Huang-He Road 850, Dalian, 116029, R.P. China. ⁷ Institute of Chemistry for Functionalized Materials, College of Chemistry and Chemical Engineering, Liaoning Normal University, Huang-He Road 850, Dalian, 116029, R.P. China. ⁸ Institute of Chemistry for Functionalized Materials, College of Chemistry and Chemical Engineering, Liaoning Normal University, Huang-He Road 850, Dalian, 116029, R.P. China.
Source: Current Organic Chemistry, Volume 16, Issue 14, Jul 2012, p. 1723 - 1728
DOI: https://doi.org/10.2174/138527212800840874
- Available online: 01 Jul 2012

Abstract

By facile condensation of aromatic amines 4-aminobenzoic acid, 2-amino-4, 6-dimethylpyrimidine, 3-aminopyridine, 4- bromobenzenamine and 4-methylbenzenamine with glyoxal and formaldehyde, catalyzed by acid or base under one or two step reaction sequence, five novel (±) trans-4,5-dihydroxy-1,3-diarylimidazolidines (DHDAIs) were prepared and characterized by X-ray single crystal analysis, NMR, IR and elemental analysis.

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2012-07-01

2025-05-05

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Article Type: Research Article

Keyword(s): 3-aminopyridine; 3-diarylimidazolidines; Aromatic Amine; Base-catalysis; Debus-Radziszewski reaction; DHDAI; Formaldehyde; Glyoxal; Heterocyle; Imidazolidine

Facile Synthesis of Imidazolidines by Condensation of Aromatic Amines with Glyoxal and Formaldehyde

Abstract

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