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Volume 15, Issue 24
  • ISSN: 1385-2728
  • E-ISSN: 1875-5348

Abstract

Asymmetric Mannich-type reactions are important organic transformations that provide excellent protocols for the synthesis of optically active nitrogen-containing compounds. This article provides an overview on the development of thiourea-catalyzed asymmetric Mannich or nitro-Mannich reactions including scope, limitations, and applications of different catalytic systems.

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/content/journals/coc/10.2174/138527211798109204
2011-12-01
2025-05-19

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  • Article Type:     Research Article
Keyword(s): asymmetric catalysis; b-amino acids; bis-thiourea; hydrogen-bonding donors; Isoquinolines; Lewis basic; Mannich-type reaction; monothiourea; Nitro-Mannich; organic chemistry; organocatalysis; organocatalytic; stereoselective catalysis; Thiourea; Wittig Reaction

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