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2000
Volume 15, Issue 2
  • ISSN: 1385-2728
  • E-ISSN: 1875-5348

Abstract

Multicomponent reactions are valuable tools for the generation of diverse heterocycles. As in many fields or organic chemistry, microwave irradiation is rapidly replacing conventional heating methods in multicomponent chemistry. In this review, we present an overview of recent applications of the use of microwaves in multicomponent heterocycle synthesis. Where possible, the yield and chemo-, regio- and stereoselectivity of microwave-assisted reactions are compared with those using conventional heating.

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/content/journals/coc/10.2174/138527211793979817
2011-01-01
2025-05-19
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/content/journals/coc/10.2174/138527211793979817
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  • Article Type:
    Research Article
Keyword(s): 4-azafluorenone; 5-exo Michael cyclization; 7-exo aza-Michael cyclization; Acyclic diketones; aromatic aldehydes; arylidenemalononitrile; aza-Michael reaction; aziridines; barbituric acids; Beller's synthesis; benzimidazolyl/triazolyl; benzodiazepines; Biginelli product; Biginelli reaction; Boc-protected -amino acids; chalcones; chemoselective multicomponent reaction towards; Combinatorial Chemistry; complex (poly)cyclic systems; cyclocondensation; diastereoselective reaction; Diazepines; dielectric loss; Diels-Alder product; dipolar po-larization; enamines; enaminones; enyne cross metathesis; etidronic acid; exocyclic amine; Fmoc protecting group; Friedel-Crafts-type reaction; Fused Pyridines; Gewald reaction; Grubbs' catalyst; Heterocycles; high scaffold di-versity; ideal synthesis; imidazo-pyridines 2; Imidazoles; imines; in vacuo; indole-pyridine derivatives; ionic conduction; isocyanides; isophtha-laldehyde; Knoevenagel con-densation; Knoevenagel product; lanthanum chloride; Lewis acid; Liebeskind-Srogl cross-coupling; malonitrile; Mannich reaction; mass spectrometry and TLC experiments; Meldrum's acid; mercapto acids; microwave irradiation; Microwave-assisted Multicomponent Synthesis of Hetero-cycles; Microwave-assisted Organic Synthesis; microwave-assisted reactions; Microwaves; molecular friction; Montmorillonite; multicomponent chemistry; Multicomponent reactions; Multiple ring systems; NITROGEN HETEROCYCLES; Nucleophilic substitution; One-Pot Reactions; organic chemis-try; Organic Synthesis; oscillating electric field; phenacyl chloride; phenylpyruvic acids; plausible mechanism; pyrano quinolines; Pyrazines and Triazines; Pyridines; Pyrimidines; Pyrroles; pyruvic esters; quinolinones; Reaction Efficiency; regioisomers; Regioselectivity; selective Mannich-type reaction; spiro-fused pyr-rolidine; Spiro-pyridines; spiropiperidines; stereoselectivity; steric hindrance; tautomerization; tetronic acid; thiofurfural; tricyclic pyrazoloqui-noline; UDC (Ugi/Deprotect/Cyclize); Ugi reac-tion; urea; Wolff rearrangement; zirconia nanopowder; zirconium dichloride
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