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Volume 15, Issue 2
  • ISSN: 1385-2728
  • E-ISSN: 1875-5348

Abstract

The application of microwave irradiation for the synthesis and decoration of the 2(1H)-pyrazinone scaffold as well as for the synthesis of various heterocycles starting from this core structure has been reviewed.

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/content/journals/coc/10.2174/138527211793979790
2011-01-01
2025-05-19

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  • Article Type:     Research Article
Keyword(s): 1,3-dimethyl acetylenedicarboxylate (DMAD); 2(1H)-pyrazinone scaffold; 2-deoxy-D-ribose; acetylenes; alkynyloxy; arachidonic acid; Arbuzov-type reaction; arthritis; arylboronic acids; asthma; benzylic halides; bis(pinacolato)diboron; bis-lactams; bis-reduction; Buchwald-Hartwig coupling; Buchwald-Hartwig type intramolecular cyclization; collageninduced platelet aggregation; copper(I)-thiophene carboxylate (CuTC); Cross-coupling; Cu(II)-mediated Liebeskind-Srogl reaction; CuAAC; cycloaddition-elimination reactions; D-ribose; depression; Desulfitative C3-Dimethylamination; Diels-Alder reaction; dimethoxyethane (DME); glycopeptidomimetics; glycosyl-azides; Heck coupling; Heck-product; heterocyclic compounds; heterogeneous gas-phase catalytic reactions; hitherto unknown nucleoside; HIV replication; I2-Mediated Electrophilic Cyclization; imidoylchloride; Lawesson's reagent; Liebeskind-Srogl coupling; Merrifield resin; Microwave irradiation; microwave-assisted cascade reaction; microwave-assisted Cucatalyzed Ullmann coupling; microwave-assisted desulfitative Sonogashira-type cross-coupling; microwave-assisted homo-dimerization reaction; Microwave-Assisted Organic Synthesis (MAOS); microwave-assisted solid-phase chemistry; microwave-assisted transition-metal-mediated reactions; non-nucleoside HIV-1 reverse transcriptase inhibitors (NNRTIs); nucleoside; olefins; oxalyl chloride; Paar multimode microwave apparatus; Pyrazinone; pyrazinonetriazoles; retro-Diels-Alder fragmentation; Simultaneous cooling; Sn-reagents; solid phase organic synthesis (SPOS); Sonogashira coupling; Stille coupling; Suzuki coupling; toxic stannanes; traceless-linkage; transition-metal-catalyzed cross-coupling reaction; trimethylsilylcyanide (TMS-cyanide); Tumor Necrosis Factor (TNF); Wang amide resin

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