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Volume 14, Issue 17
  • ISSN: 1385-2728
  • E-ISSN: 1875-5348

Abstract

Efforts have been made to understand the underlying mechanism and stereochemistry for the observed enantio- and diastereoselectivities in various chiral amine catalyzed Mannich reactions with special reference to proline and its analogous derivatives. Substrate scope in Mannich reaction tunable by structural modification in acceptor and donor components, recent examples, developments, and applications are discussed.

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/content/journals/coc/10.2174/138527210792927564
2010-10-01
2025-05-19

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  • Article Type:     Research Article
Keyword(s): (E)-aldimine; (PMP); absolute; absolute configuration; acetaldehyde; acyclic chiral amines; aldol reactions; amination; amino acids; amino-carbonyl; anti-(E)-enamine; anti-selectivity; Asymmetric organocatalysis; chiral amino acids; DMSO; drug intermediates; enantiomer; enantioselectivity; hydroxyketones; L-proline; mannich reaction; N-Boc-imines; organocatalysis; oxidation; proline; Proline Deri-vatives; reaction; stereoselective; stereoselective synthesis; syn-adduct

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