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2000
Volume 13, Issue 17
  • ISSN: 1385-2728
  • E-ISSN: 1875-5348

Abstract

The reactivity of 5-hydroxy-6-methyluracil (HMU) towards peroxyl radicals generated from the aerobic thermal decomposition of 2,2'-azo-bis(2-amidinopropane)dihydrochloride (AAPH) has been investigated. The oxidation product of HMU is dihydro-5,5,6-trihydroxy-6-methylpyrimidin-2,4-dion-e (94%). The relative oxidation rate of HMU vs. quercetin by peroxyl radicals generated from AAPH has been measured as 0.20 ± 0.04 at 54.6°C, hence HMU is the effective scavenger of peroxyl radicals. The overall kinetic parameters and the efficiency of radical generation from AAPH in water solution at pH 7.0 (0.1 M phosphate buffer) have been determined using HMU in temperature range 26° - 84°C.

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/content/journals/coc/10.2174/138527209789578081
2009-11-01
2025-04-30
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  • Article Type:
    Research Article
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