Significance of Total Synthesis of Bioactive Compounds

The first total synthesis and development of a variety of bioactive compounds have been accomplished mainly by using carbohydrates, if any, as chiral sources. The target molecules are macrolide antibiotics, aminoglycoside antibiotics, antifungal antibiotics, antitumor antibiotics, a side-chain of b-lactam antibiotics, enzyme inhibitors including glycosidase inhibitors, central nervous system - affecting products, nonsteroidal progesterone receptor ligands, mussel-attachment inhibitors and so on.