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2000
Volume 28, Issue 15
  • ISSN: 1385-2728
  • E-ISSN: 1875-5348

Abstract

As natural capping reagents, flaxseed gel, caprylic/capric triglyceride, aloe vera, and propylene glycol were utilized in the synthesis of ZnO-NPs in the current study. The synthesized ZnO NPs structure was characterized by Transmission Electron Microscopy (TEM), Fourier Transform Infrared (FT-IR), and X-ray Diffraction (XRD). The prepared ZnO-NPs were used as an efficient catalyst for the production of a new series of fused polynuclear heterocyclic system-based imidazoquinazoline by multicomponent reaction. The reaction was initiated by mixing 2-aminobenzimidazole, aryl/hetaryl aldehydes, and betanaphthol under solvent-free conditions at 60-70°C in the presence of a catalytic amount of the synthesized ZnO-NPs. As demonstrated by molecular docking, the prepared ligands (4, 7, 8, 9, and 11) exhibited outstanding validation as aurora kinase inhibitors in comparison to AKI-001, the prototype pentacyclic inhibitor.

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/content/journals/coc/10.2174/0113852728309261240507065414
2024-08-01
2025-01-08
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  • Article Type:
    Research Article
Keyword(s): aloe vera; Biosynthesis; docking; nanoparticles; quinazoline; zinc oxide
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